› 1b09

X-ray diffraction
2.5Å resolution

HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

Released:
DOI: 10.2210/pdb1b09/pdb
PDB entry 1b09 coloured by chain, front view.
PDB entry 1b09 coloured by chain, side view.
PDB entry 1b09 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The physiological structure of human C-reactive protein and its complex with phosphocholine.
Thompson D, Pepys MB, Wood SP
Structure 7 169-77 (1999)
PMID: 10368284

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 10 x CA
Ligand PC 5 x PC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P41212
Unit cell:
a: 193.94Å b: 193.94Å c: 134.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.242

Quick links

Citations

108 review citations

C-reactive protein: a critical update.
Pepys et al. (2003)
107 more

68 mentions without citation

Pentraxins: structure, function, and role in inflammation.
Du Clos TW. (2013)
67 more