› 1aap

X-ray diffraction
1.5Å resolution

X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR

Released:
DOI: 10.2210/pdb1aap/pdb
PDB entry 1aap coloured by chain, front view.
PDB entry 1aap coloured by chain, side view.
PDB entry 1aap coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Hynes TR, Randal M, Kennedy LA, Eigenbrot C, Kossiakoff AA
Biochemistry 29 10018-22 (1990)
PMID: 2125487

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble APP-beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 287-344; Coverage: 8%)
Gene names: A4, AD1, APP
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 35.6Å b: 38.9Å c: 73.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 not available not available
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Natural protein proteinase inhibitors and their interaction with proteinases.
Bode et al. (1992)
11 more

28 mentions without citation

Copper binding to the Alzheimer's disease amyloid precursor protein.
Kong et al. (2008)
27 more