triangle PDBeMotif: 3rzb  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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coner
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Enzyme   2.7.11.22
Classification transferase/transferase inhibitor    | release date: Wed, May 11, 2011
Title cdk2 in complex with inhibitor rc-2-23
Authors A.BECKER, E.SCHONBRUNN, H.HAN, R.ALAM, S.BETZI
Method X-RAY DIFFRACTION (resolution: 1.90Å)
PDBe Citation   
Small molecules:    search 02Z 02Z binding statistics 02Z
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
GPLGSPEFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT
ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS
MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CYCLIN-DEPENDENT KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  02Z 458A  ..         *                    *     ..                   *                ******                                               *          *         ..                                                                                                                                        
sec str:  .....eeeeeeeeee..eeeeeeee.....eeeeeee....hhhhhhhhhhhh........eeeeeee..eeeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee....................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR..PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV..VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31    ..45        55        65        75        85        95        105       115       125       135       145       ..163       173       183       193       203       213       223       233       243       253       263       273       283       293   
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..      ||||    |       | ||||    |   .. | |||   || || |  |   ||                 |   |                       |   |||||| | | || || |  | |    ||||  ||| ..  ||  |     | |   ||| |    |   ||  | |      |  |   |   |  |  |  | ||||| |||  |       |  ||  || |      |  | || **^* | |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..      ||||    |       | ||||    |   .. | |||   || || |  |   ||                 |   |                       |   ||^**| | | || || |  | |    ||||  ||| ..  ||  |     | |   ||| |    |   ||  ^**      |  |   |   |  |  |  | ||||| |||  |       |  ||  || |      |  | || || ^** |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..      ||||    |       | ||||    |   .. | |||   || || |  |   ||                 |   |                       |   || | | | | || || |  | |    ||||  ||| ..  ||  |     | |   |^***    |   ||  | |      ^***   |   |  ^***  | |||^***||  |       |  ||  || |      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..      ||******^       | ||||    |   .. | |||   || || |  |   ||                 |   |                       |   || | | | | || || |  | |    ||||  ||| ..  ||  |     | |   | |      |   ||  | |             |   |        | |||||  ||  |       |  ||  || |      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..      || |            | ||||    |   ..****||   || || |  |   ||                 |   |                       ^***** | | | | || || |  | |    ||^*****| ..  ||  |     | |   | |      ^*****  | |             |   |        | |||||  ||  |       |  ||  || |      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..      || ************************   .. |  ||   || || |  |   ||                 |   |                           |  | | | | || || |  | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  || |      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..      ||              | ||||        .. |  ||   || || |  |   ||                 |   |                           |  | ****^********  | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  || |      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..      ||              | ||||        .. *****   ***** |  |   ||                 |   |                           |  | | | | || ||    | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  || |      |  | *****     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..      ||              *****|        .. |  |    || || |  |   ||                 *****                           |  | | | | || ||    | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  || |      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..      ||              ***| |        .. |  |    || || |  |   ||                                                 |  | | | | || ||    | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  |***      |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..      **              |  | |        .. |  |    || || |  |   **                                                 |  | | | | || ||    | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  |         |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..                      ******        .. |  |    || || |  |                                                      |  | | | | || ||    | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        | |||||  ||  |       |  ||  |         |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..                         | |        .. ****    ***** |  |                                                      **** | | | || ||    | |    ||||  | | ..  ||  |     | |   | |          |   | |             |   |        **************       ****|  |         |  | ****|     ****  |  |         
search RasMol script viewer Motif-ligand binding stats  gammaturn ..                         | |        ..               |  |                                                         | | | | || ||    | |    ||||  *** ..  ||  |     | |   | |          |   | |             |   |          ||| |  ||  |           |  |         |  | ||  |     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  nest ..                         ***        ..               |  |                                                         *** *** || ||    ***    ****      ..  ||  |     ***   | |          |   ***             |   |          *** |  ||  |           |  |         |  | ||  |     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..                                    ..               ****                                                               | |****                     ..  |****           | |          |   |               |   |           ***********           ****         **********     ****  ****         
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                    ..                                                                                  | |  |                      ..  |               | |          *****               *****                                                                                
search RasMol script viewer Motif-ligand binding stats  stturn ..                                    ..                                                                                  | |  |                      ..  |               ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                    ..                                                                                  * *  *                      ..  *                                                                                                                                     

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