triangle PDBeMotif: 3r9o  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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Enzyme   2.7.11.22
Classification transferase/transferase inhibitor    | release date: Fri, Mar 25, 2011
Title cdk2 in complex with inhibitor rc-2-143
Authors A.BECKER, E.SCHONBRUNN, H.HAN, R.ALAM, S.BETZI
Method X-RAY DIFFRACTION (resolution: 1.90Å)
PDBe Citation   
Small molecules:    search Z71 Z71 binding statistics Z71
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
GPLGSPEFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT
ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS
MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CYCLIN-DEPENDENT KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  Z71 401A  ..         *                    * *   ..                   *               *******  *                                            *          *         ..                                                                                                                                        
sec str:  .....eeeeeeee......eeeeee.....eeeeeee....hhhhhhhhhhhh........eeeeeee..eeeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee....................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR..PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV..VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31    ..45        55        65        75        85        95        105       115       125       135       145       ..163       173       183       193       203       213       223       233       243       253       263       273       283       293   
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |  ||||    |       | ||||    |   ..   ||   | |  | |  |   ||                                             |    ||||| | | || || |  | |    ||||   |  ..  ||  |     | |   ||| |    |    |  | |      |  |   |   |  |  |  | ||||| |||  |      | |  |  || |      |  | || **^* | |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |  ||||    |       | ||||    |   ..   ||   | |  | |  |   ||                                             |    |^**| | | || || |  | |    ||||   |  ..  ||  |     | |   ||| |    |    |  ^**      |  |   |   |  |  |  | ||||| |||  |      | |  |  || |      |  | || || ^** |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |  ||||    |       | ||||    |   ..   ||   | |  | |  |   ||                                             |    | | | | | || || |  | |    ||||   |  ..  ||  |     | |   |^***    |    |  | |      ^***   |   |  ^***  | |||^***||  |      | |  |  || |      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |  ||******^       | ||||    |   ..   ||   | |  | |  |   ||                                             |    | | | | | || || |  | |    ||||   |  ..  ||  |     | |   | |      |    |  | |             |   |        | |||||  ||  |      | |  |  || |      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |  || |            | ||||    |   ..****|   | |  | |  |   ||                                             ^***** | | | | || || |  | |    ||^*****  ..  ||  |     | |   | |      ^*****  | |             |   |        | |||||  ||  |      | |  |  || |      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |  || ************************   ..    |   | |  | |  |   ||                                                    | | | | || || |  | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |      | |  |  || |      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |  ||              | ||||        ..    |   | |  | |  |   ||                                                    | ****^********  | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |      | |  |  || |      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |  ||              | ||||        ..    |   | |  | |  |   ||                                                    | | | | || ||    | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |      | |  |  || |      |  | ***** |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |  ||              *****|        ..    |   | |  | |  |   ||                                                    | | | | || ||    | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |      | |  |  || |      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |  ||              ***| |        ..    |   | |  | |  |   ||                                                    | | | | || ||    | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |      ***  |  |***      |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |  **              |  | |        ..    |   | |  | |  |   **                                                    | | | | || ||    | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |           |  |         |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..|  |                  ******        ..    |   | |  | |  |                                                         | | | | || ||    | |    ||||      ..  ||  |     | |   | |              | |             |   |        | |||||  ||  |           |  |         |  | || || |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |        ..    |   | **** |  |                                                         | | | | || ||    | |    ||||      ..  ||  |     | |   | |              | |             |   |        **********|  |           ****         |  | ****| |   ****  |  |         
search RasMol script viewer Motif-ligand binding stats  gammaturn ..|  |                     | |        ..    |   |      |  |                                                         | | | | || ||    | |    |***      ..  ||  |     | |   | |              | |             |   |          ||| |  ||  |           |  |         |  | ||  | |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***        ..    |   |      |  |                                                         *** *** || ||    ***    ****      ..  ||  |     ***   | |              ***             |   |          *** |  ||  |           |  |         |  | ||  | |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****                     | |        ..    |   |      ****                                                               | |****                     ..  |****           | |                              |   |           ***********           ****         ********** |   ****  ****         
search RasMol script viewer Motif-ligand binding stats  stmotif ..                         | |        ..    |   |                                                                         | |  |                      ..  |               | |                              |   |                                                         *****                  
search RasMol script viewer Motif-ligand binding stats  ststaple ..                         | |        ..    *****                                                                         | |  |                      ..  |               | |                              *****                                                                                
search RasMol script viewer Motif-ligand binding stats  stturn ..                         ***        ..                                                                                  | |  |                      ..  |               ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                    ..                                                                                  * *  *                      ..  *                                                                                                                                     

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