triangle PDBeMotif: 3r8z  
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Enzyme   2.7.11.22
Classification transferase/transferase inhibitor    | release date: Thu, Mar 24, 2011
Title cdk2 in complex with inhibitor rc-1-136
Authors A.BECKER, E.SCHONBRUNN, H.HAN, R.ALAM, S.BETZI
Method X-RAY DIFFRACTION (resolution: 1.85Å)
PDBe Citation   
Small molecules:    search Z63 Z63 binding statistics Z63
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
GPLGSPEFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT
ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS
MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CYCLIN-DEPENDENT KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  Z63 440A  ..         *       *            *     ..                       *                *** **                                               *          *          ..Z63 ..                                                                                                                                           
sec str:  .....eeeeeeeee...eeeeeeee.....eeeeeee.......hhhhhhhhhhhh.........eeeeeee..eeeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee............... ............hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhh....hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR..TEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP... ..THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31    ..41        51        61        71        81        91        101       111       121       131       141       151  ... ..160       170       180       190       200       210       220       230       240       250       260       270       280       290      
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |    ||    |       | ||||    |   .. ||    |   |  |    |  |   ||   |  |          |   |                       |   |||||| | | || || |  | |      |||| |   ..PS00004..     ||  |  || |||   |||||  | |   ||  | |      |  ||         |  |  | ||||| |||  |      | |   | || |      |  | || **^* | |  || || |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    ||    |       | ||||    |   .. ||    |   |  |    |  |   ||   |  |          |   |                       |   ||^**| | | || || |  | |      |||| |   ..PS00005..     ||  |  || |||   |||||  | |   ||  ^**      |  ||         |  |  | ||||| |||  |      | |   | || |      |  | || || ^** |  || || |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |    ||    |       | ||||    |   ..**|    |   |  |    |  |   ||   |  |          |   |                       |   || | | | | || || |  | |      |||| |   ..PS00006..     ||  |  || |||   |^***  | |   ||  | |      ^***|         ^***  | |||^***||  |      | |   | || |      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |    ******^       | ||||    |   ..  |    |   |  |    |  |   ||   |  |          |   |                       |   || | | | | || || |  | |      |||| |   ..PS00007..     ||  |  || |||   | ||   | |   ||  | |      |   |               | ||| |  ||  |      | |   | || |      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |     |            | ||||    |   ..  ^*****   |  |    |  |   ||   |  |          |   |                       ^***** | | | | || || |  | |      ^*****   ..PS00008..     ||  |  || |||   | ||   | ^*****  | |      |   |               | ||| |  ||  |      | |   | || |      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |     ************************   ..           |  |    |  |   ||   |  |          |   |                           |  | | | | || || |  | |      ||||     ..PS00107..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |      | |   | || |      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |                  | ||||        ..           |  |    |  |   ||   |  |          |   |                           |  | ****^********  | |      ||||     ..PS00108..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |      | |   | || |      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |                  | ||||        ..           |  |    |  |   ||   |  |          |   |                           |  | | | | || ||    | |      ||||     ..alphabetamotif..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |      | |   | || |      |  | *****     |  || || |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |                  *****|        ..           |  |    |  |   ||   |  |          *****                           |  | | | | || ||    | |      ||||     ..asxmotif..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |      | |   | || |      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |                  ***| |        ..           |  |    |  |   ||   |  |                                          |  | | | | || ||    | |      ||||     ..asxturn..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |      ***   | |***      |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |                  |  | |        ..           |  |    |  |   **   |  |                                          |  | | | | || ||    | |      ||||     ..betabulge..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |            | |         |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..|  |                  ******        ..           |  |    |  |        |  |                                          |  | | | | || ||    | |      ||||     ..betabulgeloop..     ||  |  || |||   | ||   |     |   | |      |   |               | ||| |  ||  |            | |         |  | || ||     |  || || |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |        ..           ****    ****        ****                                          **** | | | ****|    | |      ||||     ..betaturn..     ||  |  |****|   | ||   |     |   | |      |   |               ****| |  |****            | |         |  | ****|     ******** |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***        ..                   |  |                                                         *** *** || ||    ***      ****     ..nest..     ||  |  |  ***   | ||   |     |   ***      |   |                 *** |  ||  |            | |         |  |  |  |     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****                     | |        ..                   ****                                                               | |****                      ..niche..     |****  |    |   | ||   |     |   |        |   |                  ***********            ***         ****  ****     ****  ****         
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..                         | |        ..                                                                                      | |  |                       ..schellmannloop..     |      ******   | ||   |     |   |        |   |                                                                                       
search RasMol script viewer Motif-ligand binding stats  stmotif ..                         | |        ..                                                                                      | |  |                       ..stmotif..     |               | ||   |     |   |        *****                                                                                       
search RasMol script viewer Motif-ligand binding stats  ststaple ..                         | |        ..                                                                                      | |  |                       ..ststaple..     |               | |*****     *****                                                                                                    
search RasMol script viewer Motif-ligand binding stats  stturn ..                         ***        ..                                                                                      | |  |                       ..stturn..     |               ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                    ..                                                                                      * *  *                       ..REP00000..     *                                                                                                                                     

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