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Enzyme   3.1.1.47
Classification hydrolase    | release date: Thu, Nov 13, 2008
Title crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by diisopropylfluorophosphate
Authors B.J.BAHNSON, U.SAMANTA
Method X-RAY DIFFRACTION (resolution: 2.30Å)
PDBe Citation   
Small molecules:    search DFP DFP binding statistics DFP
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chains A,B sequence:
AAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFG
SMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYL
RTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSED
QRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIG
HMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHI
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
member of: GENE3D:searchG3DSA_3.40.50.1820PANTHER:searchPTHR10272/searchPTHR10272_SF9PFAM:searchPF03403PIRSF:searchPIRSF018169SUPERFAMILY:searchSSF53474UniProt:searchQ13093
JMol viewer RasMol script viewer  DFP 473A  ..                                                                                                  **                                                                                                                      ***                                                                            **                                                                         
sec str:  ............eeeeeeeee......eeeeeeeee.......ee...hhhhhhhhhhhh..hhhhhhhhhhhhh..ee..ee.........eeeeeee.........hhhhhhhhhh...eeeee........eeee..hhhhhhhh..eeee....hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh............hhhhhh..eeeeeeeeee.hhhhhhhhhhhhhh....eeeee.......hhhhhhhh...eeeeee....hhhhhhhhhh.......eeeeee...hhhhhhhhhhh.hhhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhh......eee.......
sequence :  ..TKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTT
seq num:  ..54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294       304       314       324       334       344       354       364       374       384       394       404       414         
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..     | | |         | | |||             | |               | |           |  | | ||  |                 |    |    |  ||||||        ||||       | | ||| |       | |  ||                          | |   | | | |  |  || || | |     || | |   || || ||         |  |   || || |       |  |        |  ||  |     ||| |  |  |     | |     ||||| |        | |         | |      |  | |||| ||  || |^**
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..     | | |         | ^**||             | |               | |           |  | | ||  |                 |    |    |  ||||||        ||||       | | ||| |       ^**  ||                          | |   | | | |  |  || || | |     || | |   || || ||         |  |   || || |       |  |        |  ||  |     ^** |  |  |     ^**     ||||| |        ^**         | |      |  | |||| ||  || | | 
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..     | | |         | | |||             | |               | |           |  | | ||  |                 |    |    |  ||||||        ||||       | ^***| |         |  ||                          | |   | | | |  |  || || | |     || | |   ^***| ||         |  |   || || |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |      |  | |||| ||  || | | 
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..     | | |         | | |||             | |               | |           |  | | ||  |                 ^*****    ^*****|||        ||||       |   | | |         |  ||                          | |   | | | |  |  || || | |     || | |   ||  | ||         |  |   || || |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |      |  | |||| ||  ^***** 
search RasMol script viewer Motif-ligand binding stats  LIPASE_SER ..     | | |         | | |||             | |               | |           |  | | ||  |                              || |||        ||||       |   | | |         |  ||                          | |   | | | |  |  || || | ******^*** |   ||  | ||         |  |   || || |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |      |  | |||| ||   | | | 
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..     | | |         | | |||             | |               | |           |  | | ||  |                              || |||        ||||       |   | | |         *****                          | |   | | | |  |  || || |        |   |   ||  | ||         |  |   || || |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |      |  | |||| ||   | | | 
search RasMol script viewer Motif-ligand binding stats  asxmotif ..     | | |         | | |||             | |               | |           |  | | ||  |                              || |||        ||||       ***** | |         |  |                           | |   | | | |  |  || || |        |   |   ||  | ||         |  |   || || |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |      |  | |||| ||   | | | 
search RasMol script viewer Motif-ligand binding stats  asxturn ..     | | |         | | |||             | |               | |           |  | | ||  |                              || |||        ***|             | |         |  |                           | |   | | | |  |  || |***        |   |   ||  ***|         |  |   || || |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |      |  | |||***|   | | | 
search RasMol script viewer Motif-ligand binding stats  betaturn ..     | | |         | ****|             | |               | |           **** | ||  |                              *****|        ||||             | |         ****                           | |   | | | |  ****| |           |   |   ||  |  |         |  |   ****| |       |  |        |  |****      |  |  |  |             ||||| |                    | |      **** ||||  |   | | | 
search RasMol script viewer Motif-ligand binding stats  gammaturn ..     | | |         | | | |             | |               | |           |  | ***|  |                              |  | |        ||||             | |                                        | |   | | | |  |  || |           |   |   ||  |  |         |  |    |  | |       |  |        |  ||  |      |  |  |  |             ||||| |                    | |           |***  |   | | | 
search RasMol script viewer Motif-ligand binding stats  nest ..     | | |         | | | |             | |               ***           |  |    |  |                              |  ***        ****             ***                                        ***   | | | |  |  |***           |   |   ||  |  |         |  |    |  | |       |  |        |  ||  |      |  |  |  |             ****| |                    ***           ***|  |   | | | 
search RasMol script viewer Motif-ligand binding stats  niche ..     *****         *** | |             ***                             ****    ****                              |    |         ***                                                              *** ***  *******           |   |   |*******         ****    ******       ****        ********      ****  ****                 ***                                     ****   | *** 
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..                     | | |                                                                                       ******                                                                                                     |   |   |                                                                                                                                         | |   
search RasMol script viewer Motif-ligand binding stats  stmotif ..                     *****                                                                                                                                                                                                  |   |   |                                                                                                                                         | |   
search RasMol script viewer Motif-ligand binding stats  ststaple ..                     | |                                                                                                                                                                                                    *********                                                                                                                                         | |   
search RasMol script viewer Motif-ligand binding stats  stturn ..                     ***                                                                                                                                                                                                                                                                                                                                                      ***   

Assembly 2     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain B : PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
member of: GENE3D:searchG3DSA_3.40.50.1820PANTHER:searchPTHR10272/searchPTHR10272_SF9PFAM:searchPF03403PIRSF:searchPIRSF018169SUPERFAMILY:searchSSF53474UniProt:searchQ13093
JMol viewer RasMol script viewer  DFP 473B  ..                                                                                                  **                                                                                                                      ***                       *                                                    **                                                                          
sec str:  ............eeeeeeeee......eeeeeeeee.......ee...hhhhhhhhhhhhh.hhhhhhhhhhhhh..ee..ee.........eeeeeee.........hhhhhhhhhhh..eeeee........eeee..hhhhhhhh..eeee....hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh............hhhhhh..eeeeeeeeee.hhhhhhhhhhhhhh....eeeee.........hhhhh....eeeeee....hhhhhhhhhh.......eeeeee...hhhhhhhhhhh.hhhhhhhh......hhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhhhh....eee........
sequence :  ..TKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTN
seq num:  ..54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294       304       314       324       334       344       354       364       374       384       394       404       414          
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |           |    |    |  ||||||        ||||       | | ||| |       | |                   |   |   || |||   | |     || ||| || | |     || | |   || || ||         |  |       | |       |  |       || |||  |     ||| |  |  |  |  | |     ||||           | | |       | |  |  |  |  |||| ||  || |^***
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..     | | |         | ^**|              | |               | |           |  | | ||  |  |  |           |    |    |  ||||||        ||||       | | ||| |       ^**                   |   |   || |||   | |     || ||| || | |     || | |   || || ||         |  |       | |       |  |       || |||  |     ^** |  |  |  |  ^**     ||||           ^** |       | |  |  |  |  |||| ||  || | |  
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |           |    |    |  ||||||        ||||       | ^***| |                             |   |   || |||   | |     || ||| || | |     || | |   ^***| ||         |  |       | |       |  |       || |||  |      |  |  |  |  |  |       ||||           |   |       | |  |  |  |  |||| ||  || | |  
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |           ^*****    ^*****|||        ||||       |   | | |                             |   |   || |||   | |     || ||| || | |     || | |   ||  | ||         |  |       | |       |  |       || |||  |      |  |  |  |  |  |       ||||           |   |       | |  |  |  |  |||| ||  ^*****  
search RasMol script viewer Motif-ligand binding stats  LIPASE_SER ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |                        || |||        ||||       |   | | |                             |   |   || |||   | |     || ||| || | ******^*** |   ||  | ||         |  |       | |       |  |       || |||  |      |  |  |  |  |  |       ||||           |   |       | |  |  |  |  |||| ||   | | |  
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |                        || |||        ||||       |   | | |                             |   |   || |||   | |     || ||| || |       || | |   ||  | ||         |  |       | |       |  |       || |||  |      |  |  |  |  |  |       ||||           |   |       | |  |  |  *****|| ||   | | |  
search RasMol script viewer Motif-ligand binding stats  asxmotif ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |                        || |||        ||||       ***** | |                             |   |   || |||   | |     || ||| || |       || | |   ||  | ||         |  |       | |       |  |       || |||  |      |  |  |  |  |  |       ||||           |   |       | |  |  |  |  | || ||   | | |  
search RasMol script viewer Motif-ligand binding stats  asxturn ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |                        || |||        ||||             | |                             |   |   || |||   | |     || ||| |***       || | |   ||  ***|         |  |       | |       |  |       || |||  |      |  |  |  |  |  |       ||||           |   |       | |  |  |  |  | |***|   | | |  
search RasMol script viewer Motif-ligand binding stats  betaturn ..     | | |         | | ||              | |               | |           |  | | ||  |  |  |                        |****|        ||||             | |                             |   |   |****|   | |     ****|| |          **** |   ||  |  |         |  |       | |       |  |       ****||  |      |  |  |  |  |  |       ||||           |   |       | |  ****  **** ||  |   | | |  
search RasMol script viewer Motif-ligand binding stats  gammaturn ..     | | |         | | ||              | |               | |           |  | ***|  |  |  |                        |  | |        ||||             | |                             |   |   |  | |   | |      |  || |           |   |   ||  |  |         |  |       | |       |  |        |  ||  |      |  |  |  |  |  |       ||||           |   |       | |           | ||  |   | | |  
search RasMol script viewer Motif-ligand binding stats  nest ..     | | |         | | ||              | |               ***           |  |    |  |  |  |                        |  ***        ****             ***                             |   |   |  ***   | |      |  |***           |   |   ||  |  |         |  |       | |       |  |        |  ||  |      |  |  |  |  |  |       ****           |   |       ***           ***|  |   | | |  
search RasMol script viewer Motif-ligand binding stats  niche ..     *****         ******              ***                             ****    ****  ****                        |    |         ***                                             |   |   |    |   ***      *******           |   |   |*******         ****       ***       ****        ********      ****  ****  ****                      |   |                        ****   *****  
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..                     | |                                                                                         ******                                                         |   |   ******                              |   |   |                                                                                                     |   |                               | |    
search RasMol script viewer Motif-ligand binding stats  ststaple ..                     | |                                                                                                                                                        *****                                       *********                                                                                                     *****                               | |    
search RasMol script viewer Motif-ligand binding stats  stturn ..                     ***                                                                                                                                                                                                                                                                                                                                                      ***    

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