triangle PDBeMotif: 3dgr  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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coner
AstexViewer TM
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Enzyme   2.4.2.12
Classification transferase    | release date: Sun, Jun 15, 2008
Title crystal structure of human nampt complexed with adp analogue
Authors E.S.BURGOS, M.HO, S.C.ALMO, V.L.SCHRAMM
Method X-RAY DIFFRACTION (resolution: 2.10Å)
PDBe Citation   
Small molecules:    search A12 A12 binding statistics A12
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chains A,B sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKI
QEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPIT
VATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDT
VLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFK
CSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNI
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE
member of: GENE3D:searchG3DSA_3.20.140.10PANTHER:searchPTHR11098/searchPTHR11098_SF2PFAM:searchPF04095PIRSF:searchPIRSF005943SUPERFAMILY:searchSSF51690UniProt:searchP43490
JMol viewer RasMol script viewer  A12 501B  ..         *                       ..                                                                                                                                                                                                                                                                                                                                                  *     * *                                                                                    
JMol viewer RasMol script viewer  A12 501A  ..         |                       ..                                                                                                                                           *  *                                               *                                                                  *                                       * *                             *        |     | |                                                                                    
sec str:  ...hhhhh.hhhhhhhhhh....eeeeeeeeee......eee..hhhhhhhhhh.....hhhhhhhhhhhhhhhhh....hhhhhhhhhhhhh....eeeee.....eee...eeeeeee.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh...hhhh.eee.hhhhh.hhhhhhhhhhhhh.......hhhhhhhhhhhh..............hhhhhhhhhhhhhhhhhhhhhhhh....eeee....hhhhhhhhh....hhhhhh.......eeee....hhhhhhhhhhhhhhhhh..ee.....ee....eeeee....hhhhhhhhhhhhhhh..hhh.eeeeehhhhhh........eeeeeeeeee..eeee.......hhhhh......eeee.....eeee..hhhhhh.......eeeee..ee....hhhhhhhhh....
sequence :  ..FNILLATDSYKVTHYKQYPPNTSKVYSYFECRE..YEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNI
seq num:  ..9         19        29        39 ..54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294       304       314       324       334       344       354       364       374       384       394       404       414       424       434       444       454       464       474        
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION .. |  |   | |  || ||| ^***  |  |   ..      || |    |  | | ||   |          | || ||   |      | |         |  |  |  |       || ||| |        |  |   |              ||  |||| |||| ||    |  ||  |  |    | |  | || |            | |           |   |  |  |           |  |         | | |        | ||| ||| |||        |   |       || ||    | |||   |  |   |||||   |  |     | |||||| |  |    |    | | |^***| ||    |    |       |  || |       | |||  || || | ||||  | |  ||         |  |  |  |   
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE .. |  |   ^**  || |||  ^**  |  |   ..      || |    |  | | ||   |          | || ||   |      | |         |  |  |  |       || ||| |        |  |   |              ||  |||| |||| ||    |  ||  |  |    | |  | || |            | |           |   |  |  |           |  |         | | |        | ||| ||| |||        |   |       || ||    | |||   |  |   |||||   |  |     | |||||| |  |    |    | | | |^** ||    |    |       |  |^**       | |||  || || | ||||  | |  ||         |  |  |  |   
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE .. |  |     |  || |||  |    ^***   ..      || |    |  | | ||   |          | || ||   |      | |         |  |  |  |       ^***|| |        |  |   |              ||  |||| |||| ||    |  |^***  |    | |  | || |            | |           |   |  |  |           |  |         | | |        | ||| ||| |||        |   |       || ||    | |||   |  |   |||||   ^***     | |||||| |  |    |    | | | |    ||    |    |       |  |          | |||  ^***| | ||||  | |  ||         ^***  |  |   
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE .. |  |     |  || |||  |           ..******^| |    |  | | ||   |          | || ||   |      | |         |  |  |  |        | ||| |        |  |   |              ||  |||| |||| ******^  |      |    | |  | || |            | |           |   |  |  |           |  |         | | |        | ||| ||| |||        |   |       || ||    | |||   |  |   |||||   |        | |||||| |  |    |    | | | |    ||    |    |       |  |          | |||   |  | | ||||  | |  ||               |  |   
search RasMol script viewer Motif-ligand binding stats  MYRISTYL .. |  |     |  || |||  |           ..       | |    |  | | ||   |          | || ||   |      | |         |  |  |  |        | ||| |        |  |   |              ||  ||^*****|  |    |  |      ^***** |  | || |            | |           |   |  |  |           |  |         | | |        | ||| ||| |||        |   |       || ||    | |||   |  |   |||^*****        | |||||| |  ^*****    | | | |    ||    ^*****       |  |          | |^*****  | | ||||  | |  ||               |  |   
search RasMol script viewer Motif-ligand binding stats  AMIDATION .. |  |     |  || |||  |           ..       | |    |  | | ||   |          | || ||   |      | |         |  |  |  |        | ||| |        |  |   |              ||  || | || |  |    |  |             |  | || |            | |           |   |  |  |           |  |         | | |        | ||| ||| |||        |   |       ^***|    | |||   |  |   |||||   |        | |||||| |            | | | |    ||                 |  |          | |||      | | ||||  | |  ||               |  |   
search RasMol script viewer Motif-ligand binding stats  asxmotif .. |  |     |  || |||  |           ..       | |    |  | | ||   |          | || |*****      | |         |  |  |  |        ***** |        |  |   |              ||  || | || |  |    |  |             |  | || |            | |           |   |  |  |           |  |         *****        | ||| ||| |||        |   |        |  |    | |||   |  |   |||||   |        | |||||| |            | | | |    ||                 |  |          | |||      | | ||||  | |  ||               |  |   
search RasMol script viewer Motif-ligand binding stats  asxturn .. |  |     |  || |||  |           ..       | |    |  | | ||   |          | || |           | |         |  |  |  |        ***|  |        |  |   |              ||  || | || |  |    |  |             |  | || |            | |           |   |  |  |           |  |         ***          | ||| ||| |||        |   |        |  |    | |||   |  |   |||||   |        | |||||| |            | | | |    ||                 |  |          | |||      | | ||||  | |  ||               |  |   
search RasMol script viewer Motif-ligand binding stats  betabulge .. |  |     |  || |||  |           ..       | |    |  | | ||   |          | || |           | |         |  |  |  |        |  |  |        |  |   |              ||  || | || |  |    |  |             |  | || |            | |           |   |  |  |           |  |                      | ||| ||| |||        |   |        |  |    | |||   |  |   |||||   |        | |||||| |            | | | |    **                 |  |          | |||      | | ||||  | |  **               |  |   
search RasMol script viewer Motif-ligand binding stats  betabulgeloop .. |  |     |  || |||  |           ..       | |    |  | | ||   |          | || |           | |         |  |  |  |        |  |  |        |  |   |              ||  || | || |  |    |  |             |  | || |            | |           |   |  |  |           |  |                      | ||| ||| |||        |   |        |  |    *****   |  |   |||||   |        | |||||| |            | | | |                       |  |          *****      | | ||||  | |                   |  |   
search RasMol script viewer Motif-ligand binding stats  betaturn .. ****     *******||  |           ..       | |    |  | | ||   |          | || |           | |         ****  |  |        *******        ****   |              ||  || | || |  |    |  |             |  | || |            | |           |   *******           |  |                      ****| ||****|        |   |        |  |    ****|   |  |   |||||   |        ****|||| |            | | | |                       |  |          ****|      | | ||||  | |                   |  |   
search RasMol script viewer Motif-ligand binding stats  nest ..              |  ||  |           ..       ***    |  | | ||   |          ***| |           ***         |  |  |  |                          |   |              ||  |*** |***  |    |  |             |  | || |            | |           |   |                 |  |                        | | ||| | |        |   |        |  |      ***   |  |   |||||   |          ***||| |            | | ***                       |  |            ***      *** ****  | |                   |  |   
search RasMol script viewer Motif-ligand binding stats  niche ..              ********           ..              **** ***|   |             ***                       ****  ****                          |   |              ||  || ***  ****    ****             *********            ***           |   |                 ****                        | ****| | |        |   |        ****            ****   *****   |             |****            | |                           ****                               ***                   ****   
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                 ..                      *****                                                                           |   |              ||  || |                                   | |                          |   |                                             |   | *****        |   |                                  |    |             | |              | |                                                                                           
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                 ..                                                                                                      *****              ****** |                                   | |                          *****                                             ***** | |          *****                                  ******             | |              | |                                                                                           
search RasMol script viewer Motif-ligand binding stats  stturn ..                                 ..                                                                                                                              ***                                   ***                                                                                  ***                                                                    ***              ***                                                                                           

chain B : NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE
member of: GENE3D:searchG3DSA_3.20.140.10PANTHER:searchPTHR11098/searchPTHR11098_SF2PFAM:searchPF04095PIRSF:searchPIRSF005943SUPERFAMILY:searchSSF51690UniProt:searchP43490
JMol viewer RasMol script viewer  A12 501B  ..                                 ..                                                                                                                                           *  *                                               *                                                                  *                                         *                             *                                                                                                     
JMol viewer RasMol script viewer  A12 501A  ..         *                     * ..                                                                                                                                           |  |                                               |                                                                  |                                         |                             |        *     * *                                                                                    
sec str:  ...hhhhh.hhhhhhhhhh....eeeeeeeeee......eee..hhhhhhhhhh.....hhhhhhhhhhhhhhhhh....hhhhhhhhhhhhh....eeeee.....eee...eeeeeee.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh...hhhh.eee.hhhhh.hhhhhhhhhhhhh.......hhhhhhhhhhhh..............hhhhhhhhhhhhhhhhhhhhhhhh....eeee....hhhhhhhh.....hhhhh........eeee....hhhhhhhhhhhhhhhhh..ee.....ee....eeeee....hhhhhhhhhhhhhhh..hhh.eeeeehhhhhh........eeeeeeeeee..eeee.......hhhhh......eeee.....eeee..hhhhhh.......eeeee..ee....hhhhhhhhhh...
sequence :  ..FNILLATDSYKVTHYKQYPPNTSKVYSYFECRE..YEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNI
seq num:  ..9         19        29        39 ..54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294       304       314       324       334       344       354       364       374       384       394       404       414       424       434       444       454       464       474        
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION .. |  |   | || || ||| ^***  |  |   ..      || |     | |    |   |          | || |           | |         |  |  |  |       || ||| |        |  |   |              ||  |||| |||| || | ||  ||| | ||    | |  | || |            | |           |   |  |        |   | |  |         | | |        ||||| ||| |||                    || ||    | |||   |  |   |||||   |  |     | |||||| |  |    |    | | |^***|     | ||   |       |  || |       | |||  || || ||||||  | |  |||  |     |  || |  |   
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE .. |  |   ^**| || |||  ^**  |  |   ..      || |     | |    |   |          | || |           | |         |  |  |  |       || ||| |        |  |   |              ||  |||| |||| || | ||  ||| | ||    | |  | || |            | |           |   |  |        |   | |  |         | | |        ||||| ||| |||                    || ||    | |||   |  |   |||||   |  |     | |||||| |  |    |    | | | |^**     | ||   |       |  |^**       | |||  || || ||||||  | |  |||  |     |  || |  |   
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE .. |  |   |  | || |||  |    ^***   ..      || |     | |    |   |          | || |           | |         |  |  |  |       ^***|| |        |  |   |              ||  |||| |||| || | ||  |^*** ||    | |  | || |            | |           |   |  |        |   | |  |         | | |        ||||| ||| |||                    || ||    | |||   |  |   |||||   ^***     | |||||| |  |    |    | | | |        | ||   |       |  |          | |||  ^***| ||||||  | |  |||  |     ^***| |  |   
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE .. |  |   |  | || |||  |           ..******^| |     | |    |   |          | || |           | |         |  |  |  |        | ||| |        |  |   |              ||  |||| |||| ******^  | |   ||    | |  | || |            | |           |   |  |        |   | |  |         | | |        ||||| ||| |||                    || ||    | |||   |  |   |||||   |        | |||||| |  |    |    | | | |        | ||   |       |  |          | |||   |  | ||||||  | |  |||  |     |   | |  |   
search RasMol script viewer Motif-ligand binding stats  MYRISTYL .. |  |   |  | || |||  |           ..       | |     | |    |   |          | || |           | |         |  |  |  |        | ||| |        |  |   |              ||  ||^*****|  | | ||  | |   |^***** |  | || |            | |           |   |  |        |   | |  |         | | |        ||||| ||| |||                    || ||    | |||   |  |   |||^*****        | |||||| |  ^*****    | | | |        | ^*****       |  |          | |^*****  | ||||||  | |  |||  |     |   | |  |   
search RasMol script viewer Motif-ligand binding stats  AMIDATION .. |  |   |  | || |||  |           ..       | |     | |    |   |          | || |           | |         |  |  |  |        | ||| |        |  |   |              ||  || | || |  | | ||  | |   |       |  | || |            | |           |   |  |        |   | |  |         | | |        ||||| ||| |||                    ^***|    | |||   |  |   |||||   |        | |||||| |            | | | |        |  |           |  |          | |||      | ||||||  | |  |||  |     |   | |  |   
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