2ypa: Sequences

PDBeMotif: 2ypa

		Sequences				3D motifs				Ligand environment				Ligand bonds

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Classification:	immune system \| release date: Tue, Oct 30, 2012
Title:	structure of the scl:e47:lmo2:ldb1 complex bound to dna
Authors:	C.PORCHER, D.KARIA, E.J.MANCINI, E.PONSELE, K.EL OMARI, K.TULADHAR, O.PLAT, P.VYAS, R.PATIENT, S.J.HOOSDALLY
Method:	X-RAY DIFFRACTION (resolution: 2.80Å)

PDBe Citation

Small molecules:

Ligand bond colours:

covalent

ionic

hydrogen

electrostatic

van-der-waals

plane-atom

plane-plane

undefined

- Click here to show 5Å bonds

Chain A sequence:
MGSSHHHHHHSQDPEISDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKL
LNDQEEEGTQR

Chain B sequence:
MADLSLEEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPK
AA

Chain C sequence:
MGSSHHHHHHSQDPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQD
GLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKING

Chain D sequence:
GGSGGHMGSGGDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDE

Residue colours: hydrophilic hydrophobic intermediate

Assembly 1

View the assembly/model: (

)

Motif search

chain:

Sequence numbers:

Using:	φ/ψ residues code secondary structures
	coordinates of: Cαs Side-chain

View the fragment:

chain A : T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 member of: GENE3D:G3DSA_4.10.280.10, PANTHER:PTHR13864/PTHR13864_SF16, PFAM:PF00010, PROSITE PROFILES:PS50888, SMART:SM00353, SUPERFAMILY:SSF47459, UniProt:P17542
`sec str:`	`...hhhhhhhhhhhhhhhhhhhhhhhhhhhhhh...........hhhhhhhhhhhhhhhhhhhhhhh..`
`sequence :`	`..PHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEE`
`seq num:`	`..182 192 202 212 222 232 242`
`CAMP_PHOSPHO_SITE`	`.. \|\| \|\| \| *^ \| \| \|`
`PKC_PHOSPHO_SITE`	`.. \|\| \|\| \| \| \| \| \| \|`
`CK2_PHOSPHO_SITE`	`.. \|\| \|\| \| \| ^*** \| \|`
`betaturn`	`.. ***** \| \| \| \|`
`niche`	`.. ** **`

chain B : TRANSCRIPTION FACTOR E2-ALPHA member of: GENE3D:G3DSA_4.10.280.10, PANTHER:PTHR11793/PTHR11793_SF7, PFAM:PF00010, PROSITE PROFILES:PS50888, SMART:SM00353, SUPERFAMILY:SSF47459, UniProt:P15923
`sec str:`	`..hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhhhhhh..`
`sequence :`	`..EKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPK`
`seq num:`	`..539 549 559 569 579 589 599`
`PKC_PHOSPHO_SITE`	`..\| \| ^** \| \| \| \|`
`CK2_PHOSPHO_SITE`	`..* \| \| \| \| \| \| \|`
`nest`	`.. *** \| \| \| \| \|`
`niche`	`.. * \| \| **`
`stmotif`	`.. \| \| *****`
`stturn`	`.. ***`

chain C : RHOMBOTIN-2 member of: GENE3D:G3DSA_2.10.110.10, PANTHER:PTHR24208, PFAM:PF00412, PROSITE PATTERNS:PS00478, PROSITE PROFILES:PS50023, SMART:SM00132, SUPERFAMILY:SSF57716, UniProt:P25791
`ZN` `1159C`	`..* * * *`
`ZN` `1158C`	`..\| \| \| \| * * * *`
`ZN` `1157C`	`..\| \| \| \| \| \| \| \| * * * *`
`ZN` `1156C`	`..\| \| \| \| \| \| \| \| \| \| \| \| * * * *`
`sec str:`	`.............eeeee..eee....................eeee..eeehhhhhhhhhh..ee......ee....eeeee..eeee.................eeeee..eeee..hhhhhhhh.`
`sequence :`	`..CGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKIN`
`seq num:`	`..30 40 50 60 70 80 90 100 110 120 130 140 150`
`PKC_PHOSPHO_SITE`	`..\| \|\| \| \| \| \| \| \| \| \| \|\|\|\|\| \|\| \| \| \| \| \| \| \| \| \| \| \| ^**\|\| \| \|\| \| \| \| \| \|\| \| \| \| \| \|`
`TYR_PHOSPHO_SITE`	`..\| \|\| \| \| \| \| \| \| \| \| \|\|\|\|\| \|\| \| \| \| \| \| \| \| \| \| \| \| ******^\| \| \| \| \| \|\| \| \| \| \| \|`
`MYRISTYL`	`..\| ^*** \| \| \| \| \| \| \|^*\| \| \| \| \| \| ^*** \| \| \| \|\| \| \| \| \| \| \| \|\| \| \| \| \| \|`
`AMIDATION`	`..\| \| \| \| \| \| \| \| \| \| \| \|\|\| \|^* ^* \| \| \| \| \| \| \| \|\| \| \| \| \| \| \| \|\| \| \| \| \| \|`
`LIM_DOMAIN_1`	`..^^*************^^^^** \| \| \| ^^****************^^^^****\| \| \| \| \| \|`
`betaturn`	`.. \| \| \| \| ** \| \|\| \| \| \| \| \| \| \| \| \| \| \| ** \| \|`
`gammaturn`	`.. \| \| \| \| \| \|\| \| \| \| \| \| \| \| \| \| \| \| *** \| \|`
`nest`	`.. * * *\| \| \| \| * \| \| \| \| *** \| \|`
`niche`	`.. ** * \| \|`
`ststaple`	`.. *****`

chain D : LIM DOMAIN-BINDING PROTEIN 1 member of: PANTHER:PTHR10378/PTHR10378_SF7, UniProt:Q86U70
`sec str:`	`...eee....ee.........ee..eeee...`
`sequence :`	`..DVMVVGEPTLMGGEFGDEDERLITRLENTQ`
`seq num:`	`..300 310 320`
`CK2_PHOSPHO_SITE`	`..* \|\| \|\|\|\| \| ^*** ^*`
`MYRISTYL`	`.. ^*****\| \|`
`nest`	`.. \| \|*** \|`
`niche`	`.. * **`

chain E : EBOX FORWARD
`sec str:`	`.............`
`sequence :`	`..ACCATCTGTTC`
`seq num:`	`..4`

chain F : EBOX REVERSE
`sec str:`	`.............`
`sequence :`	`..GAACAGATGGT`
`seq num:`	`..22`

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