triangle PDBeMotif: 2xwu  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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coner
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Enzyme   6.3.2.19
Classification ligase/nuclear protein    | release date: Fri, Nov 5, 2010
Title crystal structure of importin 13 - ubc9 complex
Authors F.BONO, M.GRUENWALD
Method X-RAY DIFFRACTION (resolution: 2.80Å)
PDBe Citation   
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPP
LFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
Chain B sequence:
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGAS
ALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQ
GRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCE
ALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHS
RALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHK
AQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETI
DVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKY
DLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHI
LGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDF
APMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQA
LKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRS
LMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYT
ADY
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : SUMO-CONJUGATING ENZYME UBC9
member of: CATH:search3.10.110.10GENE3D:searchG3DSA_3.10.110.10PANTHER:searchPTHR24067/searchPTHR24067_SF51PFAM:searchPF00179PROSITE PATTERNS:searchPS00183, PROSITE PROFILES:searchPS50127, SMART:searchSM00212SUPERFAMILY:searchSSF54495UniProt:searchP63279
sec str:  ..hhhhhhhhhhhhhhhhhhh.....eeeeee.....eeeeeeeeeee..........eeeeeee..........eeee................hhhhh.........hhhhhhhhhhhhhhh.......hhhhhhhhhhhhhhhhhhhhhhhhhh...
sequence :  ..MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
seq num:  ..1         11        21        31        41        51        61        71        81        91        101       111       121       131       141       151     
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..  |    |       |  | |  |      | ||| |  |     | **^* ||||        |  |  |          ||  || ||| ||| ||     |  || | |      |  | | ||   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..  |    |       |  | |  |      | ||| |  |     | || | ||||        |  |  |          ||  || ||| ||| ||     |  |^** |      |  | | ||   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..  |    |       |  | |  |      | ||| |  |     | || ^***||        |  |  |          ||  || ||| ||^***     |  ||   |      |  | | ||   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..  ^*****       |  | |  |      | ||| |  |     | || | ||||        |  |  |          ||  || ||| ||| ||     |  ||   |      |  | | ||   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  AMIDATION ..               |  | |  |      | ||| |  |     ^*** | ||||        |  |  |          ||  || ||| ||| ||     |  ||   |      |  | | ||   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  UBIQUITIN_CONJUGAT_1 ..               |  | |  |      | ||| |  |       |  | ||||        |  |  |          ***********^****|     |  ||   |      |  | | ||   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  asxturn ..               |  | |  |      | ||| |  |       |  | ||||        |  |  |           |  || |||  || ||     |  ||   |      |  | ***|   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..               |  | |  |      ***** |  |       |  | ||||        |  |  |           |  |*****  || ||     |  ||   |      |  | |  |   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  betaturn ..               |  | ****      ****| |  |       |  ******        |  |  |           |  |****|  ****|     |  ||   |      |  | |  |   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  nest ..               |  | |  |        *** |  |       |  | ||||        |  |  |           |  |  ***   |  |     |  ||   |      |  | |  |   |   | |  |            |  |  
search RasMol script viewer Motif-ligand binding stats  niche ..               **** ****            ****       *********        *******           ****  | |   ****     ****|   |      **** ****   |   | ****            ****  
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                                  *****                                 | |                *****                  |   |                       
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                  | |                                   | |                                       *****                       
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                  ***                                   ***                                                                   

chain B : IMPORTIN13
member of: GENE3D:searchG3DSA_1.25.10.10PANTHER:searchPTHR12363/searchPTHR12363_SF29PFAM:searchPF03810/searchPF08389PROSITE PROFILES:searchPS50166, SMART:searchSM00913SUPERFAMILY:searchSSF48371UniProt:searchO94829
sec str:  .....hhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhh.hhhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhhhhhh.....hhhhhhhhhhhh....hhhhhhhhhhhhhhhhhhhhhhh..hhhhhhhhhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhh....hhhhhhhhhhhhhh..hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh..hhhhhhhhhhhhhhhhh..........hhhhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhhhh...hhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh... ...hhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhh...hhhhhhhhhhhhhhhhhhhhhh..hhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhh..hhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhhhhhhhh....... ...hhhhhhhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhhhhhhhhhhhhhhhhhh...hhhhhhhhhhhhh...hhhhhhhhhhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhhhhh..hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh.........hhhhhhhhhhhhh....hhhhhhhhhhhhhhhhhh.
sequence :  ..LDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQA..PVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTS... ..YSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISH... ..PNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGL
seq num:  ..19        29        39        49        59        69        79        89        99        109       119       129       139       149 ..156       166       176       186       196       206       216       226       236       246       256       266       276       286       296       306       316       326       336       346       356       366       376       386       396       406       416       426       436       446        ... ..461       471       481       491       501       511       521       531       541       551       561       571       581       591       601       611       621       631       641       651  ... ..674       684       694       704       714       724       734       744       754       764       774       784       794       804       814       824       834       844       854       864       874       884       894       904       914       924       934       944        
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..              |  | |  |  ||      |  | || ||| |  |  |     |             |  |      | |              |   |              |  |             ..  ||    |            | |||      |   ||              |  |  |              |  | |              |  |     |  |  | | || |  |    |  || ||  |         | |                ^***     |  |         |  || |      ^***         |  | | ||                        |  |  |  ||  ||  |         |   |                    |   | ..PS00001.. |   |    |   | || |  ^***        |  |     |   |     |  |  |  |             |  |  |   |  | ||    | |||                |||| |  ||         |  ||  || |   | |  ||     |  |    | |       |  | | |  | | ..PS00001.. |  ||    |  |||   | |  | |       |   | ||| |                       || | |      |  |          |  ||  |            |   |            ||||||  |           |  | |  ||| ||      |  || |                      |    ||  |                       |  |  | | ||  |   |   |  |   |  ||            | 
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..              |  | |  |  ||      |  | || ||| |  |  |     |             |  |      ^**              |   |              |  |             ..  ||    |            | ^**      |   ||              |  |  |              |  | |              |  |     |  |  | | || |  |    |  || ||  |         | |                         |  |         |  || |                   |  | | ||                        |  |  |  ||  ||  |         |   |                    |   | ..PS00005.. |   |    |   | || |              |  |     |   |     |  |  |  |             |  |  |   |  ^**|    | |||                |||| |  ||         |  ||  || |   | |  ||     |  |    ^**       |  | | |  | | ..PS00005.. |  ||    |  |||   | |  | |       |   ^**|| |                       || | |      |  |          |  ||  |            |   |            ||||||  |           |  | |  ^** ||      |  || |                      |    ||  |                       |  |  | ^**|  |   |   |  |   |  ||            | 
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..              |  | |  |  ||      |  | || ||| |  |  |     |             |  |                       |   |              |  |             ..***|    |            |  |       |   ||              |  |  |              |  | |              |  |     ^***  | | ^***  |    |  || ||  |         | |                         |  |         |  || |                   ^*** | ||                        |  |  ^***|  |^***         |   |                    |   ^*..PS00006.. |   |    |   ^*** |              |  |     |   |     |  |  |  |             |  |  |   |     |    | |||                |||| |  ||         |  ||  || |   | |  ||     |  |              |  | | ^*** ^*..PS00006.. |  ||    |  |||   | |  | |       |   |  ^***                       ^*** |      |  |          |  ||  |            |   |            ||||||  |           |  | |   |  ||      |  || |                      |    |^***                       |  |  | | ||  |   |   |  |   |  ||            | 
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..              |  | |  |  ||      |  | || ||| |  |  ******^             |  |                       |   |              |  |             ..   |    |            |  |       |   ||              |  |  |              |  | |              |  |           | | || |  |    |  || ||  |         | |                         |  |         |  || |                      | | ||                        |  |      |  |             |   |                    |   | ..PS00007.. |   |    |   | |  |              |  |     |   |     |  |  |  |             |  |  |   |     *******^||                |||| |  ||         |  ||  || |   | |  ||     |  |              |  | | |      ..PS00007.. |  ||    |  |||   | |  | |       |   |  ||                          |   |      |  |          |  ||  |            |   |            ||||||  |           |  | |   |  ||      |  || |                      |    |                           |  |  | | ||  |   |   |  |   |  ||            | 
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..              |  | |  |  ||      |  | || ||| |  |  |                   |  |                       |   |              |  |             ..   ^*****            |  |       ^*****              |  |  |              |  | |              |  |           | | || |  |    |  || ||  |         | |                         |  |         |  || |                      | | ||                        |  |      |  |             |   |                    |   | ..PS00008.. |   |    |   | |  |              |  |     |   |     |  |  |  |             |  |  |   |          |  ||                |||| |  ||         |  ||  || |   | |  ||     |  |              ^***** |      ..PS00008.. |  ||    |  |||   | |  | |       |   |  ||                          |   |      |  |          |  ||  |            |   |            ||||||  |           |  | |   |  ||      |  || |                      ^*****                           |  |  | | ||  |   |   |  |   |  ||            ^*
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..              |  | |  *****      |  | *****| |  |  |                   |  |                       |   |              |  |             ..                     |  |       |   |               |  |  |              |  | |              |  |           | | || |  |    ********  |         | |                         |  |         |  || |                      | | ||                        |  |      |  |             |   |                    |   | ..alphabetamotif.. |   |    |   | |  |              |  |     |   |     |  |  |  |             |  |  |   |          *****                |||| *****         |  |***** |   | *****     |  |                 |   |      ..alphabetamotif.. *****    *****|   | |  | |       |   *****                          |   |      |  |          |  ||  |            |   |            ||||||  |           |  | |   *****      |  || |                                                       |  |  | | ||  |   |   |  |   *****              
search RasMol script viewer Motif-ligand binding stats  asxmotif ..              |  | |  |  |       |  | || | | |  |  |                   |  |                       |   |              |  |             ..                     |  |       |   |               |  |  |              |  | |              |  |           | | || |  |    |  |  ||  |         | |                         |  |         |  || |                      | | ||                        |  |      |  |             |   |                    |   | ..asxmotif.. |   |    |   | |  |              |  |     |   |     |  |  |  |             |  |  |   |          |  |                 |||| |  |          |  ||  |  |   | |  |      |  |                 |   |      ..asxmotif.. |  |     |  | |   | |  | |       |   |  |                           |   |      |  |          |  ||  |            |   |            ||||||  |           |  | |   |  |       |  || |                                                       |  |  | | ||  |   |   |  |   *****              
search RasMol script viewer Motif-ligand binding stats  asxturn ..              |  ***  |  |       |  | || | | |  |  |                   |  |                       |   |              |  |             ..                     |  |       |   |               |  |  |              |  | |              |  |           | | || |  |    |  |  ||  |         | |                         |  |         |  || |                      | | ||                        |  |      |  |             |   |                    |   | ..asxturn.. |   |    |   | |  |              |  |     |   |     |  |  |  |             |  |  |   |          |  |                 |||| |  |          |  ||  |  |   | |  |      |  |                 |   |      ..asxturn.. |  |     |  | |   | |  ***       |   |  |                           |   |      |  |          |  ||  |            |   |            ||||||  |           |  | |   |  |       |  || |                                                       |  |  | | ||  |   |   |  |   |  |               
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