2ht8: Sequences

PDBeMotif: 2ht8

		Sequences				3D motifs				Ligand environment				Ligand bonds

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Enzyme:	3.2.1.18
Classification:	hydrolase \| release date: Tue, Jul 25, 2006
Title:	n8 neuraminidase in complex with oseltamivir
Authors:	A.J.HAY, D.J.STEVENS, G.M.BL, J.J.SKEHEL, L.F.HAIRE, P.J.COLLINS, R.J.RUSSELL, S.J.GAMBLIN, Y.P.LIN
Method:	X-RAY DIFFRACTION (resolution: 2.40Å)

PDBe Citation

Small molecules:

G39

Ligand bond colours:

covalent

ionic

hydrogen

electrostatic

van-der-waals

plane-atom

plane-plane

undefined

- Click here to show 5Å bonds

Chain A sequence:
TYMNNTEAICDAKGFAPFSKDNGIRIGSRGHIFVIREPFVSCSPIECRTFFLTQGSLLNDKHSNGTVKDRSPFRTLMSVE
VGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDSKAVAVIHYGGVPTDVVNSWAGDILRTQESSCTCIQGDCYWVM
TDGPANRQAQYRIYKANQGRIIGQTDISFNGGHIEECSCYPNDGKVECVCRDGWTGTNRPVLVISPDLSYRVGYLCAGIP
SDTPRGEDTQFTGSCTSPMGNQGYGVKGFGFRQGTDVWMGRTISRTSRSGFEILRIKNGWTQTSKEQIRKQVVVDNLNWS
GYSGSFTLPVELSGKDCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDYEVADWSWHDGAILPFDIDKM

Residue colours: hydrophilic hydrophobic intermediate

Assembly 1

View the assembly/model: (

)

Motif search

chain:

Sequence numbers:

Using:	φ/ψ residues code secondary structures
	coordinates of: Cαs Side-chain

View the fragment:

chain A : NEURAMINIDASE member of: CATH:2.120.10.10, GENE3D:G3DSA_2.120.10.10, PFAM:PF00064, SUPERFAMILY:SSF50939, UniProt:Q07599
`G39` `800A`	.. * * * ** * * * *
`sec str:`	`.................eeeee.hhhhhhh....eeeeeeeeee....eeeeeeeeeee..hhhhh...........eeeee.....hhhhheeee....eeeee....eeeeeee......eeeeee...eeeeee.......ee.....eee..eeeeeeee.......eeeeeee....eeeeeee..........eeee....eeee..........eeeee.....eeeee...................................eeee..eeeeee.......eeeeeeee..........eeeeeeeeeeeee...................eeeeeeeeeee........eeeeeeeee.....................`
`sequence :`	`..TYMNNTEAICDAKGFAPFSKDNGIRIGSRGHIFVIREPFVSCSPIECRTFFLTQGSLLNDKHSNGTVKDRSPFRTLMSVEVGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDSKAVAVIHYGGVPTDVVNSWAGDILRTQESSCTCIQGDCYWVMTDGPANRQAQYRIYKANQGRIIGQTDISFNGGHIEECSCYPNDGKVECVCRDGWTGTNRPVLVISPDLSYRVGYLCAGIPSDTPRGEDTQFTGSCTSPMGNQGYGVKGFGFRQGTDVWMGRTISRTSRSGFEILRIKNGWTQTSKEQIRKQVVVDNLNWSGYSGSFTLPVELSGKDCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDYEVADWSWHDGAILPFDI`
`seq num:`	..83 93 103 113 123 133 143 153 163 172 182 192 202 212 222 232 242 252 262 272 282 292 302 313 323 332 344 354 364 374 384 395 405 12 421 431 442 452 462
`ASN_GLYCOSYLATION`	.. ^* \|\|\|\|\| \|\| \| \| \|\| \|\|\|\| \| \| ^\|\| \| \|\| \|\|\| \| \|\|\|\| \| \| \| \| \| \| \| \| \| \|\|\|\| \| \| \| \| \| \| \| \| \| \| \| \| \|\| \| \|\|\| \|\|\|\|\| \| ^** \| \|\| \|\| \| \| \| \| \|
`PKC_PHOSPHO_SITE`	.. \| \| \|\|\|\|\| \|\| \| \| \|\| \|\|\|\| \| \| \|\|^\| \| \|\| \|\|\| \| \|\|\|\| \| \| \| \| \| \| \| \| \| \|^ \| ^ ^ \| \| \| \| \| \| ^\| \| \|\|\| \|^\| \| \| \| \|^**\| \| \| \| \| \|
`CK2_PHOSPHO_SITE`	.. \| \| \|\|\|\|\| \|\| \| ^* \|\|\|\| \| \| \|\|^* \| \|\| \|\|\| \| \|\|\|\| ^* \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| ^* \|\|\| \|^* \| \| \| \|^* \| \| ^*** \|
`MYRISTYL`	.. \| \| \|\|^*** \| \| \| \|^* \| \|\|\| \|\| \| \|\| \|^* \|\|\|\| ^*** \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \|\|\| \| \| \| \| \| \|\| \| \| \| \| \|
`AMIDATION`	.. \| \| \|\|\|\|\| \|\| \| \| \| \| \|\| \| \| \|\|\| \|\| \| \|\| \| \| ^*** \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \|\|\| \| \| \| \| \| \|\| \| \| \| \| \|
`alphabetamotif`	.. \| \| \|\|\|\|\| \|\| \| \| \| \| \|\| \| \| \|\|\| \|\| \| \|\| \| \| \|\|\|\| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \|\|\| \| \| \| \| ***** \| \| \| \| \|
`asxturn`	.. \| \| *\|\| \|\| \| \| \| \| \|\| * \|\|\| \|\| \| \|\| \| \| *\| \| \| \| \| \| \| \| * \| \| \| \| \| \| \|\|\| \| \| \| \| \| \|\| \| \| \| \| \|
`betaturn`	.. \| \| \|\|\|\|** \| \| \| \| \|\| \| \|\| \| \|\| \| \| \|\|\|\| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \|\|\| \| \| **\| \| \| \| \| \|
`gammaturn`	.. \| \| \|\|\|\| \| \| \| \| \| \|\| \| * \| \| \|\| * \|\|\|\| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \|\|\| \| \| \| \| \| \| \| \| \| \|
`nest`	.. \| \| ** \| \| \| \| \| \| \| \| \|\| * * \| \| \| \| \| * \| \| \| \| \| \| * \| \| \| \| \| \| \| \| ***
`niche`	.. * \| \| \| \| * ** * * ** \| \| *
`stturn`	.. * \| * \| ***
`Catalytic site`	`.. * *`

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