triangle PDBeMotif: 2goo  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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Enzyme   2.7.11.30
Classification transferase    | release date: Thu, Apr 13, 2006
Title ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Authors G.P.ALLENDORPH, S.CHOE
Method X-RAY DIFFRACTION (resolution: 2.20Å)
PDBe Citation   
Small molecules:    search NDG NDG binding statistics NDG
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chains A,D sequence:
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCV
PTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Chains B,E sequence:
GSQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCM
KYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIR
Chains C,F sequence:
AILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPE
VYFCCCEGNMCNEKFSYFPEME
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : BONE MORPHOGENETIC PROTEIN 2
member of: CATH:search2.10.90.10GENE3D:searchG3DSA_2.10.90.10PANTHER:searchPTHR11848/searchPTHR11848_SF143PFAM:searchPF00019PRINTS:searchINHIBINAPROSITE PATTERNS:searchPS00250, PROSITE PROFILES:searchPS51362, SMART:searchSM00204SUPERFAMILY:searchSSF57501UniProt:searchP12643
sec str:  .....eee..eee.........eee..eee..eee.......hhhhh.hhhhhhhhhhhhhh......eeeeeeeeeeeeeee.....eeeeeeeeeeeeeeeee
sequence :  ..SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
seq num:  ..12        22        32        42        52        62        72        82        92        102          
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION .. | |      | | ||||  |||        |   |       |^***     |  || | ||                    | |       | |       
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE .. ^**      | | ||||  |||        |   |       | |       |  || | ||                    | |       | |       
search RasMol script viewer Motif-ligand binding stats  TGF_BETA_1 ..          | | ||||  ***********^***^       | |       |  || | ||                    | |       | |       
search RasMol script viewer Motif-ligand binding stats  asxturn ..          *** ||||  |||                    | |       |  || ***|                    | |       | |       
search RasMol script viewer Motif-ligand binding stats  betabulge ..              ||||  |**                    | |       |  || |  |                    | |       | |       
search RasMol script viewer Motif-ligand binding stats  nest ..              ****  |                      ***       |  || |  |                    ***       ***       
search RasMol script viewer Motif-ligand binding stats  niche ..                 ****                                |  *******                                        
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                     *****                                             

chain B : BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE IA
member of: CATH:search2.10.60.10GENE3D:searchG3DSA_2.10.60.10PANTHER:searchPTHR23255/searchPTHR23255_SF50PFAM:searchPF01064SUPERFAMILY:searchSSF57302UniProt:searchP36894
sec str:  ....eeee............eeee..eeeeeeee.....eeeeeeee...hhhhhhhh.......eeeeee................
sequence :  ..PFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPV
seq num:  ..34        44        54        64        74        84        94        104       114  
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION .. ||     | |     ^*** | |          | |        | || |     | || |          | |  |       
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE .. ||     | |          | |          | |        | || |     ^**| |          | |  |       
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE .. ||     | |          | |          | |        | || |     | || |          | |  |       
search RasMol script viewer Motif-ligand binding stats  betabulge .. **     | |          | |          | |        | || |     | || |          | |  |       
search RasMol script viewer Motif-ligand binding stats  nest ..        ***          | |          ***        | |***     | || |          ***  |       
search RasMol script viewer Motif-ligand binding stats  niche ..        ***          | |                     ***        ******            ****       
search RasMol script viewer Motif-ligand binding stats  stturn ..                     ***                                ***                          

chain C : ACTIVIN RECEPTOR TYPE 2A
member of: CATH:search2.10.60.10GENE3D:searchG3DSA_2.10.60.10PANTHER:searchPTHR23255/searchPTHR23255_SF64PFAM:searchPF01064PRINTS:searchACTIVIN2RSUPERFAMILY:searchSSF57302UniProt:searchP27038
JMol viewer RasMol script viewer  NDG 403C  ..                                     * *                                  *              *  
JMol viewer RasMol script viewer  NDG 402C  ..                *                    | |                                  |              |  
sec str:  ....eeeeee.hhhhhh...eeeee........eeeeeeeeee..eeeeeeeeeee.hhhhh....eee.......eeeee........eee..
sequence :  ..TQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFP
seq num:  ..8         18        28        38        48        58        68        78        88          
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..             | |^*** |  |           | |^***    ||       | || |    |||||         | |||||     
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..             | |  || |  |           | |        ||       | || |    |**^*         | |||||     
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..             | |  || |  |           ^**        ||       | || |    | |           | |||||     
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..             | |  ^***  |                      ||       | || |    | |           | |||||     
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..             | |   ^*****                      ||       | || |    | |           ^*****|     
search RasMol script viewer Motif-ligand binding stats  betabulge ..             | |                               **       | || |    | |           | ||| |     
search RasMol script viewer Motif-ligand binding stats  betaturn ..             | |                                        | ****    | |           ****| |     
search RasMol script viewer Motif-ligand binding stats  nest ..             ***                                        | || |    | |             *** |     
search RasMol script viewer Motif-ligand binding stats  niche ..                                                        ******    ***              ****     

chain D : BONE MORPHOGENETIC PROTEIN 2
member of: CATH:search2.10.90.10GENE3D:searchG3DSA_2.10.90.10PANTHER:searchPTHR11848/searchPTHR11848_SF143PFAM:searchPF00019PRINTS:searchINHIBINAPROSITE PATTERNS:searchPS00250, PROSITE PROFILES:searchPS51362, SMART:searchSM00204SUPERFAMILY:searchSSF57501UniProt:searchP12643
sec str:  ......eee..eeehhhhh....eee..eee..eee.......hhhhh.hhhhhhhhhhhhhh......eeeeeeeeeeeeeee.....eeeeeeeeeeeeeeeee
sequence :  ..KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
seq num:  ..11        21        31        41        51        61        71        81        91        101       111 
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..  | |      | | ||||  |||        |   |    |  |^***        |  |  |                    | |       |||       
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..  ^**      | | ||||  |||        |   |    |  | |          |  |  |                    | |       |||       
search RasMol script viewer Motif-ligand binding stats  TGF_BETA_1 ..           | | ||||  ***********^***^    |  | |          |  |  |                    | |       |||       
search RasMol script viewer Motif-ligand binding stats  asxturn ..           *** ||||  |||                 |  | |          |  |  |                    | |       |||       
search RasMol script viewer Motif-ligand binding stats  betabulge ..               ||||  |**                 |  | |          |  |  |                    | |       |**       
search RasMol script viewer Motif-ligand binding stats  betaturn ..               ||||  |                   **** |          |  |  |                    | |       | |       
search RasMol script viewer Motif-ligand binding stats  nest ..               ****  |                      ***          |  |  |                    ***       ***       
search RasMol script viewer Motif-ligand binding stats  niche ..                  ****                                   *******                                        

chain E : BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE IA
member of: CATH:search2.10.60.10GENE3D:searchG3DSA_2.10.60.10PANTHER:searchPTHR23255/searchPTHR23255_SF50PFAM:searchPF01064SUPERFAMILY:searchSSF57302UniProt:searchP36894
sec str:  .....eeee............eeee..eeeeeeee.....eeeeeeee...hhhhhhhh.......eeeeee...hhhhhh.........
sequence :  ..LPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVI
seq num:  ..33        43        53        63        73        83        93        103       113     
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..         | ||  | ^*** | |        | |||        | || |     | || |        | |||  |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..         | ||  |      | |        | |||        | || |     ^**| |        | |||  |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..         | ||  |      | |        | |||        | || |     | || |        | |||  |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..         | ||  |      | |        *****        | || |     | || |        | |||  |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..         | ||  |      | |        ***||        | || |     | || |        | |||  |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..         | ||  |      | |        *****        | || |     | || |        | |||  |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..         | ||  |      | |        ****|        | || |     | || |        ****|  |         
search RasMol script viewer Motif-ligand binding stats  nest ..         ***|  |      | |          ***        | |***     | || |          ***  |         
search RasMol script viewer Motif-ligand binding stats  niche ..         *******      | |                     ***        ******            ****         
search RasMol script viewer Motif-ligand binding stats  stturn ..                      ***                                ***                            

chain F : ACTIVIN RECEPTOR TYPE 2A
member of: CATH:search2.10.60.10GENE3D:searchG3DSA_2.10.60.10PANTHER:searchPTHR23255/searchPTHR23255_SF64PFAM:searchPF01064PRINTS:searchACTIVIN2RSUPERFAMILY:searchSSF57302UniProt:searchP27038
JMol viewer RasMol script viewer  NDG 401F  ..                                      * *  *                               *              *  
JMol viewer RasMol script viewer  NDG 400F  ..                 *                    | |  |                               |              |  
sec str:  .....eeeeee.hhhhhh...eeeee........eeeeeeeeee..eeeeeeeeeee.hhhhh....eee.......eeeee........eee..
sequence :  ..ETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFP
seq num:  ..7         17        27        37        47        57        67        77        87        97 
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..              | |^*** |  |           | |^***    ||      || || |    |||||         | |||||     
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..              | |  || |  |           | |        ||      || || |    |**^*         | |||||     
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..              | |  || |  |           ^**        ||      || || |    | |           | |||||     
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..              | |  ^***  |                      ||      || || |    | |           | |||||     
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..              | |   ^*****                      ||      || || |    | |           ^*****|     
search RasMol script viewer Motif-ligand binding stats  betabulge ..              | |                               **      || || |    | |           | ||| |     
search RasMol script viewer Motif-ligand binding stats  betaturn ..              | |                                       ****| |    | |           ****| |     
search RasMol script viewer Motif-ligand binding stats  nest ..              ***                                        | || |    | |             *** |     
search RasMol script viewer Motif-ligand binding stats  niche ..                                                         ******    ***              ****     

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