triangle PDBeMotif: 1urw  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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coner
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Enzyme   2.7.1.37
Classification transferase    | release date: Tue, Nov 11, 2003
Title cdk2 in complex with an imidazo[1,2-b]pyridazine
Authors A.L.VALENTINE, A.P.THOMAS, A.PANNIFER, C.A.MINSHULL, D.W.HEATON, J.A.TUCKER, J.BREED, J.D.CULSHAW, J.J.STANWAY, K.F.BYTH, N.COOPER, R.A.NORMAN, R.A.PAUPTIT, S.E.OAKES, S.ROWSELL
Method X-RAY DIFFRACTION (resolution: 1.60Å)
PDBe Citation   
Small molecules:    search ACE ACE binding statistics ACE   search I1P I1P binding statistics I1P
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CELL DIVISION PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  I1P 1300A  ..         *  ..   *            *    ..                                 *******  *                                            *          *      ..                                                                                                                                        
JMol viewer RasMol script viewer  ACE 0A  ..***      |  ..   |            |    ..                                 |||||||  |                                            |          |      ..                                                                                                                                        
sec str:  .....eeeeeeee.....eeeeeee.....eeeeee...hhhhhhhhhh.........eeeeeee..eeeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee...hhhhh.........hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGE..YGVVYKARNKLTGEVVALKKI..TAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA..VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1           ..15        25         ..47        57        67        77        87        97        107       117       127       137       147  ..163       173       183       193       203       213       223       233       243       253       263       273       283       293   
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |  ||||  ..|       | |       |  .. |      |  | |  |   ||   |  |          |   |                       |   |||||| | | || || |  | |  |  |||| |..  ||| |     | |   |||||  | |    |  | |      |  |   |   |  |  |  | ||||| |||  |      |  |||  || |      |  | |||**^* | |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |  ||||  ..|       | |       |  .. |      |  | |  |   ||   |  |          |   |                       |   ||^**| | | || || |  | |  |  |||| |..  ||| |     | |   |||||  | |    |  ^**      |  |   |   |  |  |  | ||||| |||  |      |  |||  || |      |  | ||||| ^** |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |  ||||  ..|       | |       |  .. |      |  | |  |   ||   |  |          |   |                       |   || | | | | || || |  | |  |  |||| |..  ||| |     | |   |^***  | |    |  | |      ^***   |   |  ^***  | |||^***||  |      |  |||  || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |  ||****..^       | |       |  .. |      |  | |  |   ||   |  |          |   |                       |   || | | | | || || |  | |  |  |||| |..  ||| |     | |   | ||   | |    |  | |             |   |        | ||| |  ||  |      |  |||  || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |  || |  ..        | |       |  ..**      |  | |  |   ||   |  |          |   |                       ^***** | | | | || || |  | |  |  |^****..  ||| |     | |   | ||   | ^*****  | |             |   |        | ||| |  ||  |      |  |||  || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |  || ***..*******************  ..        |  | |  |   ||   |  |          |   |                           |  | | | | || || |  | |  |  |||| |..  ||| |     | |   | ||   |         | |             |   |        | ||| |  ||  |      |  |||  || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |  ||    ..        | |          ..        |  | |  |   ||   |  |          |   |                           |  | ****^********  | |  |  |||| |..  ||| |     | |   | ||   |         | |             |   |        | ||| |  ||  |      |  |||  || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |  ||    ..        | |          ..        |  | |  |   ||   |  |          |   |                           |  | | | | || ||    | |  |  |||| |..  ||| |     | |   | ||   |         | |             |   |        | ||| |  ||  |      *****|  || |      |  | *****     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |  ||    ..        | |          ..        |  | |  |   ||   |  |          *****                           |  | | | | || ||    | |  |  |||| |..  ||| |     | |   | ||   |         | |             |   |        | ||| |  ||  |      |  | |  || |      |  | *****     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |  ||    ..        ***          ..        |  | |  |   ||   |  |                                          |  | | | | || ||    | |  |  |||| |..  ||| |     | |   | ||   |         | |             |   |        | ||| |  ||  |      |  | |  |***      |  | ***||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |  **    ..                     ..        |  | |  |   **   |  |                                          |  | | | | || ||    | |  |  |||| |..  ||| |     | |   | ||   |         | |             |   |        | ||| |  ||  |      |  | |  |         |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |        ..                     ..        **** |  |        ****                                          **** | | | || ||    | |  |  ||****..  ||| |     | |   | ||   |         | |             |   |        ****| |  ||  |      **** |  |         |  | ****|     ****  |  |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |        ..                     ..             |  |                                                         *** *** || ||    ***  |  |***  ..  ||| |     ***   | ||   |         ***             |   |          *** |  ||  |           |  |         |  |  |  |     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****        ..                     ..             ****                                                               | |****         ****     ..  |****           | ||   |                         |   |           ***********           ****         ****  ****     ****  ****         
search RasMol script viewer Motif-ligand binding stats  ststaple ..            ..                     ..                                                                                | |  |                   ..  | |             | |*****                         *****                                                                                
search RasMol script viewer Motif-ligand binding stats  stturn ..            ..                     ..                                                                                | |  |                   ..  ***             ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..            ..                     ..                                                                                * *  *                   ..  *                                                                                                                                     

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