triangle PDBeMotif: 1s4y  
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Enzyme   2.7.1.37
Classification transferase    | release date: Mon, Jan 19, 2004
Title crystal structure of the activin/actriib extracellular domai
Authors CENTER FOR STRUCTURAL GENOMICS (JCSG), G.P.ALLENDORPH, J.GREENWALD, M.E.VEGA, S.CHO, W.H.FISCHER, W.VALE
Method X-RAY DIFFRACTION (resolution: 2.30Å)
PDBe Citation   
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chains A,C sequence:
EAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFC
CCEGNFCNERFTHLPEPG
Chains B,D sequence:
GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSC
CVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : ACTIVIN RECEPTOR TYPE IIB PRECURSOR
member of: CATH:search2.10.60.10GENE3D:searchG3DSA_2.10.60.10PANTHER:searchPTHR23255/searchPTHR23255_SF57PFAM:searchPF01064PRINTS:searchACTIVIN2RSUPERFAMILY:searchSSF57302UniProt:searchP27040
sec str:  ...eeeeee.hhhhhh...eeeee........eeeeeeeeee..eeeeeeeeeee.hhhhh..............eeeeee............
sequence :  ..RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLP
seq num:  ..5         15        25        35        45        55        65        75        85         
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..            | |^*** |  |           | |^***             | || | |                | |||||     
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..            | |  || |  |           ^**                 | || | |                | |||||     
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..            | |  ^***  |                               | || | |                | |||||     
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..            | |   ^*****                               | || | |                ^*****|     
search RasMol script viewer Motif-ligand binding stats  betaturn ..            | |                                        ****** |                  ||| |     
search RasMol script viewer Motif-ligand binding stats  nest ..            ***                                        |  | | |                  *** |     
search RasMol script viewer Motif-ligand binding stats  niche ..                                                       **** ***                   ****     

chain B : INHIBIN BETA A CHAIN
member of: CATH:search2.10.90.10GENE3D:searchG3DSA_2.10.90.10PANTHER:searchPTHR11848/searchPTHR11848_SF133PFAM:searchPF00019PROSITE PATTERNS:searchPS00250, PROSITE PROFILES:searchPS51362, SMART:searchSM00204SUPERFAMILY:searchSSF57501UniProt:searchP08476
sec str:  .............eee..eee....hhhh.eee..eee..eee...............hhhhhhhhhhhh...........eeeeeeeeeeeeee.....eeeeeeeeeeeeeeee.
sequence :  ..GLECD..VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMR..PFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
seq num:  ..1    ..8         18        28        38        48        58          ..73        83        93        103       113 
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..     ..           ^**|||||  |||        |   | | | ||  ||||            .. |  |                 | | |       | |       
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..     ..           ^***||||  |||        |   | | | ||  ||||            .. |  |                 | | |       | |       
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..     ..               ||||  |||        |   | | | ^*****||            .. |  |                 | | |       | |       
search RasMol script viewer Motif-ligand binding stats  TGF_BETA_1 ..     ..               ||||  ***********^***^ | |  |  | ||            .. |  |                 | | |       | |       
search RasMol script viewer Motif-ligand binding stats  asxturn ..     ..               ||||  |||              | |  |  | ||            .. |  |                 *** |       | |       
search RasMol script viewer Motif-ligand binding stats  betabulge ..     ..               ||||  |**              | |  |  | ||            .. |  |                   | |       | |       
search RasMol script viewer Motif-ligand binding stats  nest ..     ..               ****  |                | |  |  | ||            .. |  |                   ***       ***       
search RasMol script viewer Motif-ligand binding stats  niche ..     ..                  ****                ******  ****            .. ****                                       
search RasMol script viewer Motif-ligand binding stats  stturn ..     ..                                              ***             ..                                            

chain C : ACTIVIN RECEPTOR TYPE IIB PRECURSOR
member of: CATH:search2.10.60.10GENE3D:searchG3DSA_2.10.60.10PANTHER:searchPTHR23255/searchPTHR23255_SF57PFAM:searchPF01064PRINTS:searchACTIVIN2RSUPERFAMILY:searchSSF57302UniProt:searchP27040
sec str:  ....eeeeee.hhhhhh...eeeee........eeeeeeee......eeeeeeeee.hhhhh....eee.......eeeee...hhhh.eee.....
sequence :  ..TRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEPG
seq num:  ..4         14        24        34        44        54        64        74        84        94   
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..             | |^*** |  | |  |      | |^***             | || |    | |           | |||||        
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..             | |  || |  | |  |      ^**                 | || |    | |           | |||||        
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..             | |  ^***  | |  |                          | || |    | |           | |||||        
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..             | |   ^***** |  |                          | || |    | |           ^*****|        
search RasMol script viewer Motif-ligand binding stats  betaturn ..             | |          ****                          | || |    | |             ||| |        
search RasMol script viewer Motif-ligand binding stats  nest ..             ***          |  |                          | || |    | |             *** |        
search RasMol script viewer Motif-ligand binding stats  niche ..                          ****                          ******    ***              ****        

chain D : INHIBIN BETA A CHAIN
member of: CATH:search2.10.90.10GENE3D:searchG3DSA_2.10.90.10PANTHER:searchPTHR11848/searchPTHR11848_SF133PFAM:searchPF00019PROSITE PATTERNS:searchPS00250, PROSITE PROFILES:searchPS51362, SMART:searchSM00204SUPERFAMILY:searchSSF57501UniProt:searchP08476
sec str:  ..........eee..eeehhhhhhhh.eee..eee..eee..........hhhhhhhhhhh.....eeeeeeeeeeeeee.....eeeeeeeeeeeeeeee.
sequence :  ..CDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIA..FHSTVINHYRMRG..CCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
seq num:  ..4         14        24        34        44    ..58        68 ..80        90        100       110    
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE .. |  |          ^**|||||  |          |   | | | ..             ..                 | |       |||       
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE .. |  |          ^***||||  |          |   | | | ..             ..                 | |       |||       
search RasMol script viewer Motif-ligand binding stats  MYRISTYL .. |  |              ||||  |          |   | | | ..             ..                 | |       |||       
search RasMol script viewer Motif-ligand binding stats  TGF_BETA_1 .. |  |              ||||  ***********^***^ | | ..             ..                 | |       |||       
search RasMol script viewer Motif-ligand binding stats  betabulge .. |  |              ||||  |                | | ..             ..                 | |       |**       
search RasMol script viewer Motif-ligand binding stats  nest .. |  |              ****  |                | | ..             ..                 ***       ***       
search RasMol script viewer Motif-ligand binding stats  niche .. ****                 ****                *** ..             ..                                     

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