triangle PDBeMotif: 1r42  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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coner
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Classification hydrolase    | release date: Tue, Oct 7, 2003
Title native human angiotensin converting enzyme-related carboxype (ace2)
Authors B.STAKER, D.RYAN, D.WILLIAMS, J.TANG, M.A.PATANE, M.FISHER, M.W.PANTOLIANO, N.A.DALES, P.TOWLER, S.G.PRASAD, S.MENON, T.PARSONS
Method X-RAY DIFFRACTION (resolution: 2.20Å)
PDBe Citation   
Small molecules:    search NAG NAG binding statistics NAG   search ZN ZN binding statistics ZN   search CL CL binding statistics CL
Modified residues:  search ASN ASN binding statistics ASN
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLA
QMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNE
RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL
HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGL
PNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF
HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM
KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL
GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD
Chain B sequence:
XXXXXX
Chain C sequence:
XXXXXXXXXXXXXXXXXXXX
Chain D sequence:
XXXXXXXXXXXXXXXXXX
Chain E sequence:
XXXXXXXXXXXXXX
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : ANGIOTENSIN I CONVERTING ENZYME 2
member of: GB:search11225609PANTHER:searchPTHR10514/searchPTHR10514_SF24PFAM:searchPF01401PRINTS:searchPEPDIPTASEASUPERFAMILY:searchSSF55486UniProt:searchQ9BYF1
JMol viewer RasMol script viewer  ZN 804A  ..                                                                                                                                                                                                                                                                                                                                                                   *   *                       *                                                                                                                                                                                                                     
JMol viewer RasMol script viewer  CL 803A  ..                                                                                                                                                      *                                                                                                                                                                                                            |   |                       |                                                                          **                    *                                                                                                                    
JMol viewer RasMol script viewer  NAG 802A  ..                                                                                                                                                      |                                                                                                                                                                                                            |   |                       |                 *                                                        ||                    |                                              *                                                                     
JMol viewer RasMol script viewer  NAG 801A  ..                                                              *                     *                                                                 |                                                                                                                                                                                                            |   |                       |                 |                                                        ||                    |                                              |                                                                     
JMol viewer RasMol script viewer  NAG 800A  ..       *                                                      |        *            |                                                                 |                                                                                                                                                                                                            |   |                       |                 |                                                        ||                    |                                              |                                                                     
sec str:  .....hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhh...........hhhhhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhhhhhheeee..eeeeeee...hhhhhhhhh.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh...hhhhhhhh.............hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh.........ee.hhh.......hhhhhhhhh.............hhhhh.hhhhhhhhhhhhhhh........hhhhhh...............eeeeee..eeeee.....hhhhhhhhhhhhhhhhhhhhh...hhhhh.....hhhhhhhhhhhhhhhhhhhhhhh.........hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh..hhhhhhhhhhhhhhhh..ee.........hhhhhhhhhhh....hhhhhhhhhhhhhhhhhhhh.....hhhhh....hhhhhhhhhhhhh.....hhhhhhhhhhh.....hhhhhhhhhhhhhhhhhhh................
sequence :  ..STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD
seq num:  ..19        29        39        49        59        69        79        89        99        109       119       129       139       149       159       169       179       189       199       209       219       229       239       249       259       269       279       289       299       309       319       329       339       349       359       369       379       389       399       409       419       429       439       449       459       469       479       489       499       509       519       529       539       549       559       569       579       589       599       609    
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..|  |    |  |                 |   |^***                 |   |      |  | ^***|        ^*** ||  || |  |   |    | |||  | ||| |           |  | |     |   | |  |  ||              || ||| | |   ||| ||  | ||| | |        || |||                 | |||| ||    | | | |||||  | | || || |  || |   | |||            || ||| ^***|||  |   | |     | |||  | |  |         |  |  |  || || |    |  ||  |  |    |          |  | |||| |||||  |   ^***             |   |        || |||||  ||           | |      | || ||  | |  | |  | ||| |           | |||   |  ||||^*** |         |  ||  |||  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    |  |                 |   |                     |   |      |  | | ^**          |  ||  |^**  |   |    | ^**  | ||| |           |  | |     |   ^**  |  ||              || ||| | |   ||| ||  | ||| | |        || |||                 | |||| ||    | | | |||||  | | || || |  || |   | |||            || |||     |||  |   | |     | |||  | |  |         |  |  |  || || |    |  ||  |  |    |          |  ^**||| |||||  |                    |   |        || |||||  ||           | |      | || ||  | |  | |  | ||| |           | |||   |  |||| |   |         |  ||  |||  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..^***    ^***                 |   |                     |   |      |  | | |||          |  ||  |     |   |    |  |   | ||| |           |  | |     |   |    |  ||              || ||| | |   ||| ||  | ||| | |        ^***||                 | |||| ||    | | | |||||  | | || || |  || |   | |||            || |||     |||  |   | |     | ||^*** |  |         ^***  |  || || |    |  ||  |  |    |          |  |  ||| |||||  |                    |   |        || |||||  ||           | |      | ^***|  | |  | |  | ||| |           | |||   |  |||| |   |         |  ||  |||  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..                             |   |                     |   |      |  | | |||          |  ||  |     |   |    |  |   | ||| |           |  | |     |   |    |  ||              || ||| | |   ||| ||  | ||| | |         |  ||                 | |||| |^***** | | |||||  | | || |^*****| |   | |||            || |||     |||  |   | |     | ||   | |  |               |  || || |    |  ||  |  ^*****          |  |  ||| |||||  |                    |   |        || |||||  ||           | |      | ||  |  | |  | |  | ||| |           | |||   |  |||| |   |         |  ||  |||  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  RGD ..                             |   |                     |   |      |  | | |||          |  ||  |     |   |    |  |   | ||| |           |  | |     |   |    |  ||              || ||| | |   *** ||  | ||| | |         |  ||                 | |||| ||      | | |||||  | | || |  |   | |   | |||            || |||     |||  |   | |     | ||   | |  |               |  || || |    |  ||  |                  |  |  ||| |||||  |                    |   |        || |||||  ||           | |      | ||  |  | |  | |  | ||| |           | |||   |  |||| |   |         |  ||  |||  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  ZINC_PROTEASE ..                             |   |                     |   |      |  | | |||          |  ||  |     |   |    |  |   | ||| |           |  | |     |   |    |  ||              || ||| | |    |  ||  | ||| | |         |  ||                 | |||| ||      | | |||||  | | || |  |   | |   | |||            || |||     |||  |   | |     | ||   | |  |               ***^^**^**    |  ||  |                  |  |  ||| |||||  |                    |   |        || |||||  ||           | |      | ||  |  | |  | |  | ||| |           | |||   |  |||| |   |         |  ||  |||  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..                             |   |                     |   |      |  | *****          |  ||  |     |   |    |  |   | ||| |           |  | |     |   |    *****              || ||| | |    |  ||  | ||| | |         *****                 | |||| ||      | | |||||  | | || |  |   | |   | |||            || |||     |||  |   | |     | ||   | |  |                  *****      |  ||  |                  |  *****| |||||  |                    |   |        || ||||*****           | |      | ||  |  | |  | |  ***** |           | |||   |  |||| |   |         |  |********** |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  asxmotif ..                             |   |                     |   |      |  | *****          |  ||  |     |   |    |  |   ***** |           |  | |     |   |    |  |               || ||| | |    |  ||  | ||| | |         |  |                  | |||| ||      | | |||||  | | || |  |   | |   | |||            || |||     |||  |   | |     | ||   | |  |                  || |       |  ||  |                  |  |  ||| |||||  |                    |   |        || |||||  |            | |      | ||  |  | |  | |  | ||  |           | |||   |  |||| |   |         |  ||  | |  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  asxturn ..                             |   |                     |   |      |  | ***|           |  ||  |     |   |    |  |   ***|  |           |  | |     |   |    |  |               || ||| ***    |  ||  | ||| | |         |  |                  | |||| ||      | ***||||  | | || |  |   ***   | |||            || |||     |||  |   ***     | ||   ***  |                  || |       |  ||  |                  |  |  ||| |||||  |                    |   |        || |||||  |            | |      ***|  |  | |  | |  | ||  |           | |||   |  |||| |   |         |  ||  | |  || |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  betaturn ..                             |   |                     |   |      |  | ****           ********     |   |    |  |   *******           |  | |     |   |    ****               |****|        |  ||  ****| | |         ****                  ****|| ||      | | ||||**** | || |  |         ****|            *****|     |||  |           | ||     ****                  ****       |  |****                  |  ****|****|||  |                    |   |        |****||****            | |      |  |  |  | |  | |  ****  |           ****|   |  ||****   |         |  |**** ****| |            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  nest ..                             |   |                     |   |      |  |                |  |         |   |    |  |      |  |           |  | |     |   |                       |  ***        |  ||  | *** | |                                 ***| ||      *** ****   | | || |  |           ***               ***     ***  |           | ||                            |         |  |                      |  |   |  ****|  |                    |   |        |  ****                ***      |  |  |  | |  ***    |   |             ***   |  |||| |   |         |  |         ***            |   |     |  |    | ||     
search RasMol script viewer Motif-ligand binding stats  niche ..                             |   |                     |   |      ****                ****         |   |    ****      ****           ******     |   |                       |    |        ********     | |                                    ****                 | **** ****                                      |****           ***|                            |         ****                      ****   |    | ****                    |   |        |    |                          ****  **** |         |   |                   *********   |         ****                        |   |     ****    ****     
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..                             |   |                     |   |                                       |   |                                | |     |   |                       ******                     | |                                    | |                  |   |                                            |   |             ||                            |                                      |   ******                         |   |        ******                                     |         |   |                           |   |                                     |   |             | |      
search RasMol script viewer Motif-ligand binding stats  stmotif ..                             |   |                     |   |                                       |   |                                | |     |   |                                                  | |                                    | |                  |   |                                            |   |             ||                            |                                      *****                              |   |                                                   |         |   |                           *****                                     |   |             | |      
search RasMol script viewer Motif-ligand binding stats  ststaple ..                             *****                     *****                                       *****                                | |     *****                                                  | |                                    | |                  *****                                            *****             ||                            |                                                                         *****                                                   |         *****                                                                     *****             | |      
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                                                                                                        ***                                                            ***                                    ***                                                                                     ||                            |                                                                                                                                 |         |                                                                                           ***      
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                                                                                                                                                                                                                                                                                                                      **                            *                                                                                                                                 *         *                                                                                                    

chain B : DISORDERED SEGMENT OF COLLECTRIN HOMOLOGY DOMAIN
sec str:  ........
sequence :  ..XXXXXX
seq num:  ..901   

chain C : DISORDERED SEGMENT OF COLLECTRIN HOMOLOGY DOMAIN
sec str:  ....eeee..............
sequence :  ..XXXXXXXXXXXXXXXXXXXX
seq num:  ..907       917       
search RasMol script viewer Motif-ligand binding stats  nest ..                 ***

chain D : DISORDERED SEGMENT OF COLLECTRIN HOMOLOGY DOMAIN
sec str:  ..hhhhhhhhhhhhhhhhh.
sequence :  ..XXXXXXXXXXXXXXXXXX
seq num:  ..927       937     
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..         *****  | 
search RasMol script viewer Motif-ligand binding stats  betaturn ..         ******** 

chain E : DISORDERED SEGMENT OF COLLECTRIN HOMOLOGY DOMAIN
sec str:  ......hhh.eeee..
sequence :  ..XXXXXXXXXXXXXX
seq num:  ..945       955 
search RasMol script viewer Motif-ligand binding stats  betaturn ..    ****|     
search RasMol script viewer Motif-ligand binding stats  niche ..     ****     

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