triangle PDBeMotif: 1pxp  
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Enzyme   2.7.1.
Classification transferase    | release date: Fri, Jul 4, 2003
Title human cyclin dependent kinase 2 complexed with the inhibitor n-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]- n',n'-dimethyl-benzene-1,4-diamine
Authors A.OSNOWSKI, C.MCINNES, C.MEADES, C.MIDGLEY, D.ZHELEVA, G.GRIFFITHS, G.WOOD, I.MCNAE, M.D.WALKINSHAW, M.MEZNA, M.THOMAS, P.M.FISCHER, R.YUILL, S.ANDERSON, S.WANG, S.Y.WU, W.JACKSON
Method X-RAY DIFFRACTION (resolution: 2.30Å)
PDBe Citation   
Small molecules:    search CK8 CK8 binding statistics CK8
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CELL DIVISION PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  CK8 500A  ..         *                    * *   ..                                       *****    *                                            *          *                                                                                                                                                         
sec str:  .....eeeeeeeee...eeeeeeee.....eeeeeee.......hhhhhhhhhhh..........eeeeeee..eeeeeee...eehhhhhhhhh....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee..........................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR..TEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31    ..41        51        61        71        81        91        101       111       121       131       141       151       161       171       181       191       201       211       221       231       241       251       261       271       281       291     
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |    |||   |       | ||||    |   .. |||   ||   | ||||||  |   ||   |  |          |   ||  ||                  |    ||||| | | || || || | |  |  || |  |       | |  ||  |     | |   |||||  | |    |  | |      |  |          |  |  | ||||| |||  |      | |   | || |      |  | |||**^* ||| ||               
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    |||   |       | ||||    |   .. |||   ||   | ||||||  |   ||   |  |          |   ||  ||                  |    |^**| | | || || || | |  |  || |  |       | |  ||  |     | |   |||||  | |    |  ^**      |  |          |  |  | ||||| |||  |      | |   | || |      |  | ||||| ^**|| ||               
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |    |||   |       | ||||    |   ..**||   ||   | ||||||  |   ||   |  |          |   ||  ||                  |    | | | | | || || || | |  |  || |  |       | |  ||  |     | |   |^***  | |    |  | |      ^***          ^***  | |||^***||  |      | |   | || |      |  | |||||    || ||               
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |    ******^       | ||||    |   .. |||   ||   | ||||||  |   ||   |  |          |   ||  ||                  |    | | | | | || || || | |  |  || |  |       | |  ||  |     | |   | ||   | |    |  | |                          | |||||  ||  |      | |   | || |      |  | |||||    || ||               
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |     ||           | ||||    |   .. |^*****|   | ||||||  |   ||   |  |          |   ||  ||                  ^***** | | | | || || || | |  |  |^*****       | |  ||  |     | |   | ||   | ^*****  | |                          | |||||  ||  |      | |   | || |      |  | |||||    || ||               
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |     ************************   .. | |    |   | ||||||  |   ||   |  |          |   ||  ||                         | | | | || || || | |  |  || |          | |  ||  |     | |   | ||   |         | |                          | |||||  ||  |      | |   | || |      |  | |||||    || ||               
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |     ||           | ||||        .. | |    |   | ||||||  |   ||   |  |          |   ||  ||                         | ****^********| | |  |  || |          | |  ||  |     | |   | ||   |         | |                          | |||||  ||  |      | |   | || |      |  | |||||    || ||               
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |     ||           | ||||        .. | |    |   | ||||||  |   ||   |  |          |   |*****                         | | | | || ||  | | |  |  || |          | |  ||  |     | |   | ||   |         | |                          | |||||  ||  |      | |   | || |      |  | *****    || ||               
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |     ||           *****|        .. | |    |   | ||||||  |   ||   |  |          *****|  |                          | | | | || ||  | | |  |  || |          | |  ||  |     | |   | ||   |         | |                          | |||||  ||  |      | |   | || |      |  | *****    || ||               
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |     ||           ***| |        .. | |    |   | ||||||  |   ||   |  |               |  |                          | | | | || ||  *** |  |  || |          | |  ||  |     | |   | ||   |         | |                          | |||||  ||  |      ***   | |***      |  | ***||    || ||               
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |     **              | |        .. | |    |   | ||||||  |   **   |  |               |  |                          | | | | || ||    | |  |  || |          | |  ||  |     | |   | ||   |         | |                          | |||||  ||  |            | |         |  | || ||    || ||               
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |        .. | |    |   ****||||  |        ****               ****                          | | | | ****|    | |  |  || |          | |  |****     | |   | ||   |         | |                          *******  ||  |            | |         |  | ****|    ****|               
search RasMol script viewer Motif-ligand binding stats  gammaturn ..|  |                     | |        .. | |    |   | | ***|  |                                                         | | | | || ||    | |  |  || |          | |  ||  |     | |   | ||   |         | |                            ||| |  ||  |            | |         |  |  |  |     |  |               
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***        .. ***    |   | |  | |  |                                                         *** *** || ||    ***  |  |***          ***  ||  |     ***   | ||   |         ***                            *** |  ||  |            | |         |  |  |  |     |  |               
search RasMol script viewer Motif-ligand binding stats  niche ..****                                ..        |   | **** ****                                                               | |****         ****                  |****           | ||   |                                         ***********            ***         ****  ****     ****               
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                    ..        *****                                                                         | |  |                                |               | |*****                                                                                                              
search RasMol script viewer Motif-ligand binding stats  stturn ..                                    ..                                                                                      | |  |                                |               ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                    ..                                                                                      * *  *                                *                                                                                                                                     

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