triangle PDBeMotif: 1pxm  
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Enzyme   2.7.1.
Classification transferase    | release date: Fri, Jul 4, 2003
Title human cyclin dependent kinase 2 complexed with the inhibitor 3-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2- ylamino]-phenol
Authors A.OSNOWSKI, C.MCINNES, C.MEADES, C.MIDGLEY, D.ZHELEVA, G.GRIFFITHS, G.WOOD, I.MCNAE, M.D.WALKINSHAW, M.THOMAS, P.M.FISCHER, R.YUILL, S.ANDERSON, S.WANG, S.Y.WU, W.JACKSON
Method X-RAY DIFFRACTION (resolution: 2.53Å)
PDBe Citation   
Small molecules:    search CK5 CK5 binding statistics CK5
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CELL DIVISION PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  CK5 500A  ..         *                    * *  ..                                    *******                                               *          *                                                                                                                                                         
sec str:  .....eeeeeeeee....eeeeeee.....eeeeee....hhhhhhhhhhhh.........eeeeee....eeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhh........hhh.eee.....eee...hhhhhh.................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhh..........hhhhhhhhhhhhhh.........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI..VPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31   ..44        54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294  
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |   |  || | |  |   ||                 |   ||  |                   |   |||||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |||||  | |   ||  | |      |  |   |   |  |  |  | |||||||||  |       |  ||   | |    | |||| |||**^* ||| ||| || |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |   |  || | |  |   ||                 |   ||  |                   |   ||^**| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |||||  | |   ||  ^**      |  |   |   |  |  |  | |||||||||  |       |  ||   | |    | |||| ||||| ^**|| ||| || |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |   |  || | |  |   ||                 |   ||  |                   |   || ||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |^***  | |   ||  | |      ^***   |   |  ^***  | |||^***||  |       |  ||   | |    | |||| |||||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |    ******^       | || |    |  ..    |   |  || | |  |   ||                 |   ||  |                   |   || ||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   | ||   | |   ||  | |             |   |        | |||||| ||  |       |  ||   | |    | |||| |||||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |     |            | || |    |  ..*****   |  || | |  |   ||                 |   ||  |                   ^***** ||| | | || || |  | |  |  |^*****       | |  ||  |     | |   | ||   | ^*****  | |             |   |        | |||||| ||  |       |  ||   | |    | |||| |||||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |     ************************  ..        |  || | |  |   ||                 |   ||  |                       || ||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   | ||   |     |   | |             |   |        | |||||| ||  |       |  ||   | |    | |||| |||||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |                  | || |       ..        |  || | |  |   ||                 |   ||  |                       || ||****^********  | |  |  |||| ||       | |  ||  |     | |   | ||   |     |   | |             |   |        | |||||| ||  |       |  ||   | |    | |||| |||||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |                  | || |       ..        ***** | |  |   ||                 |   ||  |                       || ||| | | || ||    | |  |  ||*****       | |  ||  |     | |   | ||   |     |   | |             |   |        | |||||| ||  |       *****   | |    *****| *****    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |                  | || |       ..        |  |  | |  |   ||                 *****|  |                       || ||| | | || ||    | |  |  |||| |        | |  ||  |     | |   | ||   |     |   | |             |   |        | |||||| ||  |       |  |    | |    | || | *****    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |                  ***| |       ..        |  |  | |  |   ||                      |  |                       || ||| | | || ||    | |  |  |||| |        | |  ||  |     | |   | ||   |     |   | |             |   |        | |||||| ||  |       |  |    ***    | || | ***||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |                     | |       ..        |  |  | |  |   **                      |  |                       || ||| | | || ||    | |  |  |||| |        | |  ||  |     | |   | ||   |     |   | |             |   |        | |||||| ||  |       |  |           | || | || ||    || ||| || |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |       ..        ******* ****                           ****                       |****| | | || ||    | |  |  ||****        | |  |****     | |   | ||   |     |   | |             |   |        **********|  |       ****           **** | ****|    ********* |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***       ..           |  | |  |                                                      |  *** *** || ||    ***  |  |***          ***  ||  |     ***   | ||   |     |   ***             |   |          *** || ||  |                        |  |  |  |     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****                     | |       ..           **** ****                                                      |    |   | |****         ****                  |****           | ||   |     |   |               |   |           ***********                        ****  ****     ****  ****         
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..                         | |       ..                                                                          ******   | |  |                                |               | ||   |     |   |               |   |                                                                                
search RasMol script viewer Motif-ligand binding stats  ststaple ..                         | |       ..                                                                                   | |  |                                |               | |*****     *****               *****                                                                                
search RasMol script viewer Motif-ligand binding stats  stturn ..                         ***       ..                                                                                   | |  |                                |               ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                   ..                                                                                   * *  *                                *                                                                                                                                     

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