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Enzyme   2.7.1.
Classification transferase    | release date: Fri, Jul 4, 2003
Title human cyclin dependent kinase 2 complexed with the inhibitor n-[4-(2,4-dimethyl-thiazol-5-yl)pyrimidin-2-yl]- n'-hydroxyiminoformamide
Authors C.MCINNES, D.I.ZHELEVA, D.P.LANE, G.KONTOPIDIS, H.MARRIAGE, I.MCNAE, K.J.STEWART, M.D.WALKINSHAW, P.M.FISCHER, P.TAYLOR, S.J.MCCLUE, S.WANG, S.Y.WU
Method X-RAY DIFFRACTION (resolution: 2.80Å)
PDBe Citation   
Small molecules:    search CK3 CK3 binding statistics CK3
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CELL DIVISION PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  CK3 500A  ..         *       *            * *  ..                                     ****                                                 *         **                                                                                                                                                         
sec str:  ......eeeeeeeee..eeeeeee......eeeeeee....hhhhhhhhhhhhh.......eeeeeee..eeeeeee...eehhhhhhh......hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee..........................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhh....hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI..VPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31   ..44        54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294  
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |  |  ||  | |  |                           |  |     |  ||         |    ||||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |||||  | | | ||| | |      |  ||         |  |  | ||||| |||  |       |  |    | |    | |||| |||**^* ||| ||  |            
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |  |  ||  | |  |                           |  |     |  ||         |    |^**| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |||||  | | | ||| ^**      |  ||         |  |  | ||||| |||  |       |  |    | |    | |||| ||||| ^**|| ||  |            
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |  |  ||  | |  |                           |  |     |  ||         |    | ||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |^***  | | | ||| | |      ^***|         ^***  | |||^***||  |       |  |    | |    | |||| ||||| |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |    ******^       | || |    |  ..    |  |  ||  | |  |                           |  |     |  ||         |    | ||| | | || || |  | |  |  |||| ||       | |  ||  |     | |   |||||  | | | ||| | |      |   |               | ||| |  ||  |       |  |    | |    | |||| ||||| |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |     |            | || |    |  ..*****  |  ||  | |  |                           |  |     |  ||         ^***** ||| | | || || |  | |  |  |^*****       | |  ||  |     | |   |||||  | ^*****| | |      |   |               | ||| |  ||  |       |  |    | |    | |||| ||||| |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |     ************************  ..    |  |  ||  | |  |                           |  |     |  ||              | ||| | | || || |  | |  |  |||| |        | |  ||  |     | |   |||||  |   | ||| | |      |   |               | ||| |  ||  |       |  |    | |    | |||| ||||| |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |                  | || |       ..    |  |  ||  | |  |                           |  |     |  ||              | ||****^********  | |  |  |||| |        | |  ||  |     | |   |||||  |   | ||| | |      |   |               | ||| |  ||  |       |  |    | |    | |||| ||||| |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |                  | || |       ..    |  *****  | |  |                           |  |     *****              | ||| | | || ||    | |  |  |||| |        | |  ||  |     | |   |||||  |   ***** | |      |   |               | ||| |  ||  |       |  |    | |    *****| ***** |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |                  | || |       ..    |  |  ||  | |  |                           |  |     |  |               | ||| | | || ||    | |  |  |||| |        | |  ||  |     | |   |||||  |   | ||  | |      |   |               | ||| |  ||  |       |  |    | |    | || | ***** |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |                  ***| |       ..    |  |  ||  | |  |                           |  |     |  |               | ||| | | || ||    | |  |  |||| |        | |  ||  |     | |   |||||  |   | ||  | |      |   |               | ||| |  ||  |       |  |    ***    | || | ***|| |  || ||  |            
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |       ..    *********** ****                           ****     ****               ****| | | *****    | |  |  |||| |        | |  |****     | |   |****  |   ****  | |      |   |               ****| |  |****       ****           **** | ****| |  ********            
search RasMol script viewer Motif-ligand binding stats  gammaturn ..|  |                     | |       ..           |  | |  |                                                         | | *** || ||    | |  |  |||| |        | |  ||  |     | |   | ||   |     |   | |      |   |                 ||| |  ||  |                        |  |  |  | |   |  |               
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***       ..           |  | |  |                                                         *** *** || ||    ***  |  |*** |        ***  ||  |     ***   | ||   |     |   ***      |   |                 *** |  ||  |                        |  |  |  | |   |  |               
search RasMol script viewer Motif-ligand binding stats  niche ..****                     | |       ..           **** ****                                                               | |****         **** ****             |****           | ||   |     |   |        |   |                  ***********                        ****  **** |   ****               
search RasMol script viewer Motif-ligand binding stats  stmotif ..                         | |       ..                                                                                   | |  |                                |               | ||   |     |   |        *****                                                                *****                  
search RasMol script viewer Motif-ligand binding stats  ststaple ..                         | |       ..                                                                                   | |  |                                |               | |*****     *****                                                                                                    
search RasMol script viewer Motif-ligand binding stats  stturn ..                         ***       ..                                                                                   | |  |                                |               ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                   ..                                                                                   * *  *                                *                                                                                                                                     

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