triangle PDBeMotif: 1ke8  
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Enzyme   2.7.1.37
Classification transferase    | release date: Wed, Nov 14, 2001
Title cyclin-dependent kinase 2 (cdk2) complexed with 4-{[(2-oxo- 1,2-dihydro-3h-indol-3-ylidene)methyl]amino}-n-(1,3- thiazol-2-yl)benzenesulfonamide
Authors A.M.HASSELL, H.N.BRAMSON, J.CORONA, L.F.KUYPER, L.M.SHEWCHUK, M.EDELSTEIN, R.T.GAMPE, S.H.DICKERSON, S.T.DAVIS, S.V.FRYE
Method X-RAY DIFFRACTION (resolution: 2.00Å)
PDBe Citation   
Small molecules:    search LS4 LS4 binding statistics LS4
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CELL DIVISION PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  LS4 299A  ..       ***                    *     ..                                    *******  *                                            *          *        ..                                                                                                                                        
sec str:  .....eeeeeeeee...eeeeeeee.....eeeeeee....hhhhhhhhhhhh.........eeeeeee..eeeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee...hhhhhh..........hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR..VPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG..VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31    ..44        54        64        74        84        94        104       114       124       134       144       ..163       173       183       193       203       213       223       233       243       253       263       273       283       293   
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |    ||    |       | || |    |   ..    |      |  | |  |   ||   |  |          |   |                       |   |||||| | | || || |  | |  |  || |  | ..  ||  |     | |   ||| |    |    |  | |      |  ||  |   |  |  |  | ||||| |||  |            | || |      |  | |||**^* | |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    ||    |       | || |    |   ..    |      |  | |  |   ||   |  |          |   |                       |   ||^**| | | || || |  | |  |  || |  | ..  ||  |     | |   ||| |    |    |  ^**      |  ||  |   |  |  |  | ||||| |||  |            | || |      |  | ||||| ^** |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |    ||    |       | || |    |   ..    |      |  | |  |   ||   |  |          |   |                       |   || ||| | | || || |  | |  |  || |  | ..  ||  |     | |   |^***    |    |  | |      ^***|  |   |  ^***  | |||^***||  |            | || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |    ******^       | || |    |   ..    |      |  | |  |   ||   |  |          |   |                       |   || ||| | | || || |  | |  |  || |  | ..  ||  |     | |   | |      |    |  | |      |   |  |   |        | |||||  ||  |            | || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |     |            | || |    |   ..*****      |  | |  |   ||   |  |          |   |                       ^***** ||| | | || || |  | |  |  |^***** ..  ||  |     | |   | |      ^*****  | |      |   |  |   |        | |||||  ||  |            | || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |     ************************   ..           |  | |  |   ||   |  |          |   |                           || ||| | | || || |  | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |                  | || |        ..           |  | |  |   ||   |  |          |   |                           || ||****^********  | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | || |      |  | |||||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |                  | || |        ..           |  | |  |   ||   |  |          |   |                           || ||| | | || ||    | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | || |      |  | *****     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |                  | || |        ..           |  | |  |   ||   |  |          *****                           || ||| | | || ||    | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | || |      |  | *****     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |                  ***| |        ..           |  | |  |   ||   |  |                                          || ||| | | || ||    | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | |***      |  | ***||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |                  |  | |        ..           |  | |  |   **   |  |                                          || ||| | | || ||    | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | |         |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..|  |                  ******        ..           |  | |  |        |  |                                          || ||| | | || ||    | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        | |||||  ||  |            | |         |  | || ||     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |        ..           **** |  |        ****                                          *****| | | ****|    | |  |  || |    ..  ||  |     | |   | |              | |      |   |  |   |        ******|  ||  |            | |         |  | ****|     ****  |  |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***        ..           |  | |  |                                                         *** *** || ||    ***  |  |***    ..  ||  |     ***   | |              ***      |   |  |   |          *** |  ||  |            | |         |  |  |  |     |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****                                ..           **** ****                                                               | |****         ****       ..  |****           | |              | |      |   |  |   |           ***********            ***         ****  ****     ****  ****         
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                    ..                                                                                   | |  |                     ..  |               | |              | |      *****  |   |                                                                                
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                    ..                                                                                   | |  |                     ..  |               | |              | |             *****                                                                                
search RasMol script viewer Motif-ligand binding stats  stturn ..                                    ..                                                                                   | |  |                     ..  |               ***              ***                                                                                                  
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                    ..                                                                                   * *  *                     ..  *                                                                                                                                     

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