triangle PDBeMotif: 1gz8  
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Enzyme   2.7.1.37
Classification transferase    | release date: Fri, May 17, 2002
Title human cyclin dependent kinase 2 complexed with the inhibitor 2-amino-6-(3'-methyl-2'-oxo)butoxypurine
Authors J.A.ENDICOTT, J.A.TUCKER, L.N.JOHNSON, M.E.NOBLE, T.G.DAVIES
Method X-RAY DIFFRACTION (resolution: 1.30Å)
PDBe Citation   
Small molecules:    search MBP MBP binding statistics MBP
Modified residues:  search CSD CSD binding statistics CSD
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CELL DIVISION PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  MBP 1300A  ..         ****    *            * *   ..                    *               ****                                               *  *                                                                                                                                                                    
sec str:  .....eeeeeeeee....eeeeeee.....eeeeeee....hhhhhhhhhhhh.........eeeeeee..eeeeeee...eehhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee...hhhhhhh................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR..VPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31    ..44        54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294  
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |  ||||    |       | || |    |   ..    ||   |      |  |                      | |                         |    ||||| | | || || |  | |  |  || |  |     | |||  ||| |   | |||   |||||  | |   ||  | |      |  |          | ||  | ||||| |||  |           || || |      |  | |||**^* | |  || || |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |  ||||    |       | || |    |   ..    ||   |      |  |                      | |                         |    |^**| | | || || |  | |  |  || |  |     | |||  ||| |   | |||   |||||  | |   ||  ^**      |  |          | ||  | ||||| |||  |           || || |      |  | ||| | ^** |  || || |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |  ||||    |       | || |    |   ..    ||   |      |  |                      | |                         |    | ||| | | || || |  | |  |  || |  |     | |||  ||| |   | |||   |^***  | |   ||  | |      ^***          ^***  | |||^***||  |           || || |      |  | ||| | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |  ||******^       | || |    |   ..    ||   |      |  |                      | |                         |    | ||| | | || || |  | |  |  || |  |     | |||  ||| |   | |||   | ||   | |   ||  | |                      |   | ||| |  ||  |           || || |      |  | ||| | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |  || |            | || |    |   ..*****|   |      |  |                      | |                         ^***** ||| | | || || |  | |  |  |^*****     | |||  ||| |   | |||   | ||   | ^*****  | |                      |   | ||| |  ||  |           || || |      |  | ||| | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |  || ************************   ..     |   |      |  |                      | |                              | ||| | | || || |  | |  |  || |        | |||  ||| |   | |||   | ||   |     |   | |                      |   | ||| |  ||  |           || || |      |  | ||| | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |  ||              | || |        ..     |   |      |  |                      | |                              | ||****^********  | |  |  || |        | |||  ||| |   | |||   | ||   |     |   | |                      |   | ||| |  ||  |           || || |      |  | ||| | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |  ||              | || |        ..     |   |      |  |                      | |                              | ||| | | || ||    | |  |  || |        | |||  ||| |   | |||   | ||   |     |   | |                      ***** ||| |  ||  |           || || |      |  | ||| | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |  ||              ***| |        ..     |   |      |  |                      ***                              | ||| | | || ||    | |  |  || |        | |||  ||| |   | |||   | ||   |     |   | |                          | ||| |  ||  |           || |***      |  | *** | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |  **                 | |        ..     |   |      |  |                                                       | ||| | | || ||    | |  |  || |        | |||  ||| |   | |||   | ||   |     |   | |                          | ||| |  ||  |           || |         |  | ||  | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..|  |                     | |        ..     |   |      |  |                                                       | ||| | | || ||    | |  |  || |        *****  ||| |   | |||   | ||   |     |   | |                          | ||| |  ||  |           || |         |  | ||  | |   |  || || |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..|  |                     | |        ..     |   |      |  |                                                       ****| | | || ||    | |  |  || |        ****|  ||| |   ****|   | ||   |     |   | |                          ****| |  ||  |           ****         |  | ||  | |   ******** |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***        ..     |   |      |  |                                                         *** *** || ||    ***  |  |***        | ***  ||| |     ***   | ||   |     |   ***                            *** |  ||  |            | |         |  | ||  | |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****                                ..     |   |      ****                                                               | |****         ****           | | |  |****           | ||   |     |   | |                             ***********            ***         ********** |   ****  ****         
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                    ..     |   |                                                                         | |  |                         *****  | |             | ||   |     |   | |                                                                           *****                  
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                    ..     *****                                                                         | |  |                         | |    | |             | |*****     ***** |                                                                                                  
search RasMol script viewer Motif-ligand binding stats  stturn ..                                    ..                                                                                   | |  |                         ***    ***             ***              ***                                                                                                  
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                    ..                                                                                   * *  *                                *                                                                                                                                     

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