triangle PDBeMotif: 1e1v  
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Enzyme   2.7.1.37
Classification protein kinase    | release date: Thu, May 11, 2000
Title human cyclin dependent kinase 2 complexed with the inhibitor nu2058
Authors J.A.ENDICOTT, L.N.JOHNSON, M.E.M.NOBLE
Method X-RAY DIFFRACTION (resolution: 1.95Å)
PDBe Citation   
Small molecules:    search ACE ACE binding statistics ACE   search CMG CMG binding statistics CMG
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CYCLIN-DEPENDENT PROTEIN KINASE 2
member of: CATH:search1.10.510.10/search3.30.200.20GENE3D:searchG3DSA_1.10.510.10/searchG3DSA_3.30.200.20PANTHER:searchPTHR24056/searchPTHR24056_SF168PFAM:searchPF00069PROSITE PATTERNS:searchPS00107/searchPS00108, PROSITE PROFILES:searchPS50011, SMART:searchSM00220SUPERFAMILY:searchSSF56112UniProt:searchP24941
JMol viewer RasMol script viewer  CMG 401A  ..         ****    *            * *  ..                    *               ****                                               *  *                                                                                                                                                                    
JMol viewer RasMol script viewer  ACE 0A  ..***      ||||    |            | |  ..                    |               ||||                                               |  |                                                                                                                                                                    
sec str:  .....eeeeee........eeeeee.....eeeeeee...hhhhhhhhhhhh.........eeeeeee..eeeeeee.....hhhhhhhh.....hhhhhhhhhhhhhhhhhhhhhh.......hhh.eee.....eee...hhhhhhh................hhhhhh......hhhhhhhhhhhhhhhhhh.......hhhhhhhhhhhhhh........hhhhh.............hhhhhh...hhhhhhhhhhhh........hhhhhhhhhhhh...........
sequence :  ..MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI..VPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
seq num:  ..1         11        21        31   ..44        54        64        74        84        94        104       114       124       134       144       154       164       174       184       194       204       214       224       234       244       254       264       274       284       294  
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |      | ||||  |   ||   |  |          | | |   |                   |   |||||| | | || || |  | |  |  || |  |     | |||  ||| |     | |  ||||||  | |   ||  | |      |  |   |   |  |  |  | ||||| |||  |      |  || | || |      |  | |||**^* ||| ||| || |         
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |      | ||||  |   ||   |  |          | | |   |                   |   ||^**| | | || || |  | |  |  || |  |     | |||  ||| |     | |  ||||||  | |   ||  ^**      |  |   |   |  |  |  | ||||| |||  |      |  || | || |      |  | ||||| ^**|| ||| || |         
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..|  |    ||    |       | || |    |  ..    |      | ||||  |   ||   |  |          | | |   |                   |   || ||| | | || || |  | |  |  || |  |     | |||  ||| |     | |  ||^***  | |   ||  | |      ^***   |   |  ^***  | |||^***||  |      |  || | || |      |  | ||||| |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..|  |    ******^       | || |    |  ..    |      | ||||  |   ||   |  |          | | |   |                   |   || ||| | | || || |  | |  |  || |  |     | |||  ||| |     | |  || ||   | |   ||  | |             |   |        | ||| |  ||  |      |  || | || |      |  | ||||| |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..|  |     |            | || |    |  ..*****      | ||||  |   ||   |  |          | | |   |                   ^***** ||| | | || || |  | |  |  |^*****     | |||  ||| |     | |  || ||   | ^*****  | |             |   |        | ||| |  ||  |      |  || | || |      |  | ||||| |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ATP ..|  |     ************************  ..           | ||||  |   ||   |  |          | | |   |                       || ||| | | || || |  | |  |  || |        | |||  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      |  || | || |      |  | ||||| |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  PROTEIN_KINASE_ST ..|  |                  | || |       ..           | ||||  |   ||   |  |          | | |   |                       || ||****^********  | |  |  || |        | |||  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      |  || | || |      |  | ||||| |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..|  |                  | || |       ..           | ||||  |   ||   |  |          | | |   |                       *****| | | || ||    | |  |  || |        | |||  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      ***** | || |      |  | ***** |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..|  |                  | || |       ..           | ||||  |   ||   |  |          | | |   |                       || ||| | | || ||    | |  |  || |        | |||  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      |  |  | || |      |  | ***** |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  asxturn ..|  |                  ***| |       ..           | ||||  |   ||   |  |          *** |   |                       || ||| | | || ||    | |  |  || |        | |||  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      |  |  | |***      |  | ***|| |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  betabulge ..|  |                     | |       ..           | ||||  |   **   |  |              |   |                       || ||| | | || ||    | |  |  || |        | |||  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      |  |  | |         |  | || || |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..|  |                     | |       ..           | ||||  |        |  |              |   |                       || ||| | | || ||    | |  |  || |        *****  ||| |     | |  || ||   |     |   | |             |   |        | ||| |  ||  |      |  |  | |         |  | || || |  || ||| || |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..****                     | |       ..           ****||  |        ****              |   |                       *****| | | ****|    | |  |  || |        ****|  |****     | |  || ||   |     |   | |             |   |        *******  |****      ****  | |         |  | ****| |  ***********         
search RasMol script viewer Motif-ligand binding stats  gammaturn ..|  |                     | |       ..             ***|  |                          |   |                          | | | | || ||    | |  |  || |        | | |  ||| |     | |  || ||   |     |   | |             |   |          ||| |  ||  |            | |         |  |  |  | |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  nest ..|  |                     ***       ..                |  |                          |   |                          *** *** || ||    ***  |  |***        | ***  ||| |     ***  || ||   |     |   ***             |   |          *** |  ||  |            | |         |  |  |  | |   |  |  |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..****                               ..                ****                          |   |                                | |****         ****           | | |  |****       ****| ||   |     |   |               |   |           ***********            ***         ****  **** |   ****  ****         
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                   ..                                              |   |                                | |  |                         *****  | |             | ||   |     |   |               |   |                                                         *****                  
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                   ..                                              *****                                | |  |                         | |    | |             | |*****     *****               *****                                                                                
search RasMol script viewer Motif-ligand binding stats  stturn ..                                   ..                                                                                   | |  |                         ***    ***             ***                                                                                                                   
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                   ..                                                                                   * *  *                                *                                                                                                                                     

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