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Enzyme   3.4.21.46
Classification hydrolase (serine protease)    | release date: Wed, Sep 13, 1995
Title mutant of factor d with enhanced catalytic activity
Authors J.E.VOLANAKIS, S.V.L.NARAYANA
Method X-RAY DIFFRACTION (resolution: 2.00Å)
PDBe Citation   
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD
YQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH
DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVSWGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : FACTOR D
member of: CATH:search2.40.10.10GENE3D:searchG3DSA_2.40.10.10PANTHER:searchPTHR24265/searchPTHR24265_SF83PFAM:searchPF00089PRINTS:searchCHYMOTRYPSINPROSITE PATTERNS:searchPS00134/searchPS00135, PROSITE PROFILES:searchPS50240, SMART:searchSM00020SUPERFAMILY:searchSSF50494UniProt:searchP00746
sec str:  ................eeeeee..eeeeeeeeee..eeee.hhhhhh.....eeeee............eeeeeeeeee.............eeeee..........................eeeeee..............eeeeee...hhhhhhhh.........eeee..............eeee..eeeeee.............eeeeehhhhhhhhhhh..
sequence :  ..ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDYQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVSWGSRVCGNRKKPGIYTRVASYAAWIDSVLA
seq num:  ..16        26        36        47        57        64        74        84        94        104       114       125       134       144       155       165       173       183       193       207       217       226       236     
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..  |    | |||  |      |  ||||   || | |   ||           |  | | || | |||         |  |   | ||||     | |            | | |  |  |  |         |  || |             |   |  |   | ||    | **^*|||||||  |  |    |   |    | | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..  |    | |||  |      |  ||||   || | |   ||           |  | | || | ^**         |  |   | ||||     ^**            | | |  |  |  |         |  || |             |   |  |   ^**|    ^**||^**|||||  |  |    |   |    | | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..  |    | |||  |      |  ||||   || | |   ||           |  | | ^***  |          |  |   | ||||                    | | |  |  ^***         |  || |             |   ^***   | ||    |  || | |||||  |  |    |   |    | | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..  ^***** |||  |      ^*****^***** | |   ||           |  | |  | |  |          |  |   | ||||                    | | |  |  |            |  || |             |   |      | ||    |  || | |||||  |  ^*****   ^***** | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  AMIDATION ..       | |||  |         ||     |  | |   ||           |  | |  | |  |          |  |   | ||||                    | | |  |  |            ^***| |             |   |      | ||    |  || | |||||  |                | | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  TRYPSIN_HIS ..       | |||  |         ||     |  | ****^*           |  | |  | |  |          |  |   | ||||                    | | |  |  |                | |             |   |      | ||    |  || | |||||  |                | | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  TRYPSIN_SER ..       | |||  |         ||     |  |     |            |  | |  | |  |          |  |   | ||||                    | | |  |  |                | |             |   |      | ||    |  |******^*****                | | |      |  ||        
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..       | |||  |         ||     |  |     |            |  | |  | |  |          |  |   | ||||                    | | |  |  |                | |             |   |      | ||    |  |  | |||||                   | | |      *****        
search RasMol script viewer Motif-ligand binding stats  betabulge ..       | |||  |         **     |  |     |            |  | |  | |  |          |  |   | ||||                    | | |  |  |                | |             |   |      | ||    |  |  | |||||                   | | |      |  |         
search RasMol script viewer Motif-ligand binding stats  betaturn ..       ****|  |                |  |     |            |  | |  | |  |          |  |   | ||||                    | | |  ****                | |             |   |      | ||    |  |  *******                   | | |      ****         
search RasMol script viewer Motif-ligand binding stats  gammaturn ..         | |  |                |  |     |            |  | |  | |  |          |  |   | |***                    | ***  |  |                | |             |   |      | ||    |  |  | |||||                   | | |                   
search RasMol script viewer Motif-ligand binding stats  nest ..         ***  |                |  |     |            |  | |  | |  |          |  |   | | |                     | |    |  |                | |             |   |      | ||    |  |  | ***||                   *** |                   
search RasMol script viewer Motif-ligand binding stats  niche ..           ****                ****     |            **** **** ****          ****   *** |                     ***    ****                ***             |   |      ****    ****  | *****                     ***                   
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                        |                                               |                                                                *****      | |           | ||||                                            
search RasMol script viewer Motif-ligand binding stats  stturn ..                                        |                                               |                                                                           ***           | ||||                                            
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                        *                                               *                                                                                         * ****                                            

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