This is just here as a test because I lose it

Term information

database cross reference
  • RETIRED_EHDAA2:0001273
  • EMAPA:16074
  • EFO:0003643
  • VHOG:0001372
  • TAO:0001178
  • EHDAA:257
  • XAO:0004091
  • ZFA:0001178

efo_slim, vertebrate_core

  • Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998).
development notes
  • After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm.
editor note
  • todo - epidermis? todo - track down EHDAA2 class in new release
has exact synonym
  • non neural ectoderm
has narrow synonym
  • epidermal ectoderm
  • epithelial ectoderm
has related synonym
  • surface ectoderm
  • ventral ectoderm
homology notes
  • In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG]
  • UBERON:0005497