This is just here as a test because I lose it

Term information

database cross reference
Subsets

uberon_slim, efo_slim, vertebrate_core, grouping_class, early_development

curator note
  • this term groups together disparate structures with different relationships.
depicted by
  • http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png
editor note
  • TODO - consider relationship to UBERON:0000091 ! bilaminar disc
external definition
  • The inner of the two layers of the blastoderm that forms during gastrulation and give rise to the definitive mesoderm and endoderm. Kimmel et al, 1995.[TAO]
  • A primary germ layer that can give rise to both mesoderm and endoderm.[AAO]
has exact synonym
  • hypoblast
has related synonym
  • future endoderm and mesoderm
  • endomesoderm
  • hypoblastus
  • mesendoderm
homology notes
  • In mammal and avian, extraembryonic endoderm such as visceral endoderm and hypoblast play essential roles in the embryonic axis formation and germ layer development. These extraembryonic tissues are generally considered to have been created in ancestral amniotes evolved from the Xenopus-type ancestor (reference 1); The endomesoderm secretes as yet unidentified signals that posteriorize the ectoderm, which would otherwise adopt an anterior fate. Our results point to a conserved function at the base of deuterostomes for beta-catenin in germ layer specification and to a causal link in the definition of the posterior part of the embryonic ectoderm by way of activating posteriorizing endomesodermal factors (reference 2).[well established][VHOG]
id
  • UBERON:0000089
see also
  • https://github.com/obophenotype/uberon/issues/437