Precursor B-cell acute lymphoblastic leukemia

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A rare acute lymphoblastic leukemia characterized by infiltration of bone marrow and peripheral blood by small to medium-sized blast cells typically positive for the B-cell markers CD19, cCD79a, and cCD22. Predilection sites for extramedullary involvement are the central nervous system, lymph nodes, spleen, liver, and testes. Patients present with evidence of bone marrow failure (i. e. thrombocytopenia, anemia, and/or neutropenia) and variable leukocyte count, as well as lymphadenopathy, hepatomegaly, splenomegaly, bone pain, and arthralgias.



Precursor B-cell acute lymphocytic leukemia

Precursor B-cell acute lymphocytic leukemia/lymphoma

Precursor B-cell acute lymphoblastic leukemia/lymphoma

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Term information

database cross reference
  • UMLS:C0006413 (E (Exact mapping: the two concepts are equivalent))
  • OMIM:615545 (BTNT (ORPHA code's Broader Term maps to a Narrower Term))
  • UMLS:C1292769 (E (Exact mapping: the two concepts are equivalent))
  • ICD-10:C83.5 (- NTBT (ORPHA code's Narrower Term maps to a Broader Term). - Inclusion term (The ORPHA code is included under a ICD10 category and has not its own code).)
  • ICD-10:C91.0 (- NTBT (ORPHA code's Narrower Term maps to a Broader Term). - Attributed (The ICD10 code is attributed by Orphanet).)
  • ICD-10:C91.0
  • OMIM:615545
  • ICD-10:C83.5
  • UMLS:C1292769
  • UMLS:C0006413
has age of onset
has inheritance
  • ORPHA:99860
part of