An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells, and manifests with easy bruising, hemorrhagic diathesis and fatigue.

Synonyms: APML Acute myeloblastic leukemia 3 Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants AML with t(15;17)(q22;q12);(PML/RARalpha) and variants AML M3

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Term information

database cross reference
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OMIM:612376

MedDRA:10001019

UMLS:C0023487

MeSH:D015473

ICD-10:C92.4

notation

ORPHA:520