Acute megakaryoblastic leukemiaGo to external page http://www.orpha.net/ORDO/Orphanet_518
A rare acute myeloid leukemia that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.
Synonyms: AML M7 Acute myeloid leukemia M7 AMKL Acute megakaryocytic leukemia
- has_annual_incidence_range some <1 / 1 000 000 and present_in some Europe and has_annual_incidence_average_value value 0.02
- has_inheritance some not genetically inherited
- has_age_of_onset some childhood
- part_of some Unclassified acute myeloid leukemia
- present_in some Europe and has_point_prevalence_range some <1 / 1 000 000