Acute monoblastic/monocytic leukemia

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Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).

Synonyms: AML M5 Acute monoblastic or monocytic leukemia

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Term information

database cross reference
  • MeSH:D007948 (E (Exact mapping: the two concepts are equivalent))
  • UMLS:C0023465 (E (Exact mapping: the two concepts are equivalent))
  • UMLS:C1318544 (E (Exact mapping: the two concepts are equivalent))
  • UMLS:C0457334 (E (Exact mapping: the two concepts are equivalent))
  • ICD-10:C92.7 (NTBT (ORPHA code's Narrower Term maps to a Broader Term))
  • MedDRA:10000871 (E (Exact mapping: the two concepts are equivalent))
  • MedDRA:10059439 (E (Exact mapping: the two concepts are equivalent))
hasDbXref

MedDRA:10059439

UMLS:C0457334

MeSH:D007948

ICD-10:C92.7

UMLS:C0023465

MedDRA:10000871

UMLS:C1318544

notation

ORPHA:514