Autosomal recessive spastic paraplegia type 76Go to external page http://www.orpha.net/ORDO/Orphanet_488594
Autosomal recessive spastic paraplegia type 76 is a rare, complex hereditary spastic paraplegia characterized by adult onset slowly progressive, mild to moderate lower limb spasticity and hyperreflexia, resulting in gait disturbances, commonly associated with upper limb hyperreflexia and dysarthria. Foot deformities (usually pes cavus) and extensor plantar responses are also frequent. Additional features may include ataxia, lower limb weakness/amyotrophy, abnormal bladder function, distal sensory loss and mild intellectual deterioration.
- present_in some Worldwide and has_point_prevalence_range some <1 / 1 000 000
- part_of some Autosomal recessive complex spastic paraplegia
- has_age_of_onset some adult
- present_in some Worldwide and has_cases/families_value value 7.0