Acute myeloid leukemia and myelodysplastic syndromes related to radiationGo to external page http://www.orpha.net/ORDO/Orphanet_164726
A subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with radiation. The neoplastic cells typically harbor unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. Patients frequently present with multilineage dysplasia and cytopenias 5-10 years after exposure.
Synonyms: AML and myelodysplastic syndromes related to radiation