A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell. [ NCI ]

Synonyms: PCD APOPTOSIS Apoptotic Process apoptosis programmed cell death Programmed Cell Death Apoptosis

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Term information

Subsets

NCIT_C61410, NCIT_C77526, NCIT_C120531

ALT DEFINITION

A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.

A form of programmed cell death triggered by internal or external signals that results in a series of characteristic morphological changes.

DesignNote

Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.

Preferred Name

Apoptosis

Semantic Type

Phenomenon or Process

UMLS CUI

C0162638

code

C17557

Term relations

Related from:
Gene_Plays_Role_In_Process