A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell. [ NCI ]
Synonyms: PCD APOPTOSIS Apoptotic Process apoptosis programmed cell death Programmed Cell Death Apoptosis
Term information
NCIT_C61410, NCIT_C77526, NCIT_C120531
A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.
A form of programmed cell death triggered by internal or external signals that results in a series of characteristic morphological changes.
Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.
Term relations
- Cell Death Process
- Biological_Process_Is_Part_Of_Process some Cell Ontogeny
- Biological_Process_Has_Result_Biological_Process some Thymic T-Cell Selection
- Biological_Process_Has_Initiator_Process some Cell Death Signaling Process
- Cleft Lip and Palate Transmembrane Protein 1-Like Protein
- Eukaryotic Translation Initiation Factor 5A-1
- E3 Ubiquitin-Protein Ligase SIAH2
- Transcription Factor AP-4
- Caspase
- Tumor Protein D53
- Apoptosis Regulator
- BCL-2 Family Protein
- Killin
- WW Domain-Containing Oxidoreductase
- Nuclear Factor NF-kappa-B p50 Subunit
- Pleckstrin Homology-Like Domain Family A Member 2
- Nucleotide-Binding Oligomerization Domain-Containing Protein 2
- Protein JTB
- CD27 Gene
- TNFRSF25 Gene
- LGALS7 Gene
- LGALS7B Gene
- SNCA Gene
- BCL7B Gene
- CASP8 Gene
- CASP3 Gene
- CASP2 Gene
- Caspase Gene
- CASP1 Gene
- STK3 Gene
- STK4 Gene
- NFKBIA Gene
- RAC1 Gene
- TRAF1 Gene
- ZNF385B Gene
- EIF5A Gene
- SIAH2 Gene
- BBC3 Gene
- TFAP4 Gene
- PSENEN Gene
- ATM Gene
- E2F1 Gene
- TP53BP2 Gene
- TNF Gene
- BRAF Gene
- STK11 Gene
- TP53AIP1 Gene
- PIK3R2 Gene
- GADD45A Gene
- PGAP2 Gene
- FADD Gene
- FASTK Gene
- DOCK1 Gene
- DAXX Gene
- CXCR4 Gene
- CDK11B Gene
- CCR8 Gene
- BCL6 Gene
- DEPTOR Gene
- SQSTM1 Gene
- TFDP2 Gene
- TPD52L1 Gene
- TNFRSF11B Gene
- TNFSF11 Gene
- PRF1 Gene
- RIPK3 Gene
- RIPK2 Gene
- PTK2B Gene
- PTPN6 Gene
- PTK2 Gene
- PMAIP1 Gene
- PAK6 Gene
- PAX3 Gene
- NRP1 Gene
- NOTCH1 Gene
- BEX3 Gene
- DUSP22 Gene
- MAPK14 Gene
- MAPK9 Gene
- MAP2K6 Gene
- MAGED1 Gene
- MAP3K7 Gene
- LGALS8 Gene
- IRF1 Gene
- ING1 Gene
- IFNA2 Gene
- HTATIP2 Gene
- TNFSF12 Gene
- TNFRSF12A Gene
- PTMA Gene
- PSMB5 Gene
- CARD8 Gene
- DNM1L Gene
- KHDRBS1 Gene
- TNFAIP3 Gene
- PERP Gene
- BECN1 Gene
- PDCD4 Gene
- PDCD1 Gene
- CAV2 Gene
- FAS Gene
- TNFRSF1B Gene
- TNFRSF1A Gene
- TNFRSF10A Gene
- YARS1 Gene
- TNFSF9 Gene
- TNFSF14 Gene
- SATB2 Gene
- FOXL2 Gene
- MX1 Gene
- CCN1 Gene
- PSEN2 Gene
- PPP1R13L Gene
- BUB1B Gene
- CALR Gene
- SFRP1 Gene
- KLLN Gene