A technique for enhancing cell-mediated immunity by: 1) artificially increasing the number of specific immunocompetent cells through inoculation of either ex-vivo expanded primarily activated cytotoxic lymphocytes or genetically engineered lymphocytes with enhanced cytotoxic ability or 2) by altering tumor cells to make them more immunogenic. [ NCI ]
Synonyms: Adoptive Cell Transfer, Adoptive Cell Immunotherapy, ACT, adoptive cellular immunotherapy, Adoptive Cell Transfer Immunotherapy, adoptive cellular therapy, Adoptive Cell Transfer Therapy, Adoptive Immunotherapy, ACT Therapy, cellular adoptive immunotherapy
A treatment used to help the immune system fight diseases, such as cancer and infections with certain viruses. T cells are collected from a patient and grown in the laboratory. This increases the number of T cells that are able to kill cancer cells or fight infections. These T cells are given back to the patient to help the immune system fight disease.
The concept does not refer to anticancer vaccines and immune modulation through the therapeutic use of cytokines, cell receptors, or other substances.
Therapeutic or Preventive Procedure