POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels. [ http://www.ncbi.nlm.nih.gov/pubmed/23398538 Orphanet:2905 ]

This is just here as a test because I lose it

Term information

database cross reference
  • UMLS:C0085404 (Orphanet:2905)
  • ICD10:D47.7 (Orphanet:2905)
  • MESH:D016878 (Orphanet:2905)
  • Orphanet:2905 (MONDO:equivalentTo)
  • MedDRA:10053869 (Orphanet:2905)
  • EFO:1001115 (MONDO:equivalentTo)
  • GARD:0007411 (Orphanet-shared)
  • DOID:14039 (MONDO:equivalentTo)
  • NCIT:C80303 (exact-label-match)
  • SCTID:79268002 (MONDO:equivalentTo)
Subsets

ordo_disease

comment

POEMS syndrome is associated with plasmacytomas and osteosclerotic lesions. The etiologic factors of this constellation of diseases are not well defined, but radiation therapy to localized lesions is often of benefit, and there is a report that autologous hematopoetic cell transplantation benefited a patient with refractory disease.

definition

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

exactMatch

http://purl.obolibrary.org/obo/NCIT_C80303

http://identifiers.org/snomedct/79268002

http://www.orpha.net/ORDO/Orphanet_2905

http://identifiers.org/mesh/D016878

http://linkedlifedata.com/resource/umls/id/C1510415

http://purl.obolibrary.org/obo/DOID_14039

http://identifiers.org/meddra/10053869

http://linkedlifedata.com/resource/umls/id/C0085404

excluded subClassOf

http://purl.obolibrary.org/obo/MONDO_0002459

has exact synonym

osteosclerotic myeloma

polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome

PEP syndrome

Crow-Fukase syndrome

Takatsuki syndrome

POEMS syndrome

has related synonym

polyneuropathy organomegaly

polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome

id

MONDO:0017364