Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms. [ https://rarediseases.info.nih.gov/diseases/7051/mixed-connective-tissue-disease ]
Term information
- GARD:0007051 (MONDO:equivalentTo)
- DOID:3492 (MONDO:equivalentTo)
- MESH:D008947 (Orphanet:809)
- SCTID:398049005 (MONDO:equivalentTo)
- UMLS:C0026272 (Orphanet:809)
- NCIT:C84892 (MONDO:equivalentTo)
- MedDRA:10027754 (Orphanet:809)
- ICD10:M35.1 (Orphanet:809)
- EFO:0007374 (MONDO:equivalentTo)
- Orphanet:809 (MONDO:equivalentTo)
gard_rare, ordo_disease
Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms.
http://identifiers.org/meddra/10027754
http://identifiers.org/snomedct/398049005
http://linkedlifedata.com/resource/umls/id/C0026272
http://purl.obolibrary.org/obo/NCIT_C84892
http://www.orpha.net/ORDO/Orphanet_809
http://identifiers.org/mesh/D008947
http://purl.obolibrary.org/obo/DOID_3492
sharp syndrome
MCTD
connective tissue disease overlap syndrome
mixed collagen vascular disease
Term relations
- overlapping connective tissue disease
- rheumatologic disorder
- secondary interstitial lung disease in childhood and adulthood associated with a connective tissue disease
- systemic inflammatory disease associated with an acquired peripheral neuropathy
- autoimmune neuropathy
- autoimmune disease of musculoskeletal system
- secondary glomerular disease
- skeletal system disease