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multiple system atrophy

^ http://www.ebi.ac.uk/efo/EFO_1001050


A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536) [ http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern ]

Synonyms: orthostatic hypotension syndrome, Shy-Drager Syndrome, Shy-McGee-Drager syndrome, Multiple system atrophy (disorder), Shy-Drager syndrome

Term info

MSH definition citation

MSH:D019578, MSH:D012791

MedDRA definition citation

MedDRA:10064060

SNOMEDCT definition citation

SNOMEDCT:230297002

UMLS definition citation

UMLS:C0393571

term editor

Gautier Koscielny, Sirarat Sarntivijai

Term relations

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