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Granular Cell Tumor

^ http://www.ebi.ac.uk/efo/EFO_1000284


An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. [ http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern ]

An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. [ NCIT:C3474 ]

Synonyms: granular cell myoblastoma, Abrikossoff's tumor, granular cell neoplasm, granular cell tumor (morphologic abnormality), granular cell tumor, Abrikossoff tumor, granular cell nerve sheath tumor, granular cell schwannoma

Term info

database cross reference
  • ICDO:9580/0 (NCIT:C3474)
  • SCTID:404035005 (MONDO:kboom-pr-1.00/0.91/26.40)
  • DOID:2411 (MONDO:equivalentTo)
  • NCIT:C3474 (exact-label-match)
  • MESH:D016586 (MONDO:ontobio)
  • ICD9:215.9 (i2s)
  • ONCOTREE:GCT (MONDO:equivalentTo)
  • UMLS:C0085167 (NCIT:C3474)
  • GARD:0009618 (MONDO:equivalentTo)
  • MONDO:0006235
  • NCIt:C3474 (http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern)
  • MESH:C535558 (MONDO:equivalentTo)
Subsets

gard_rare

closeMatch

http://identifiers.org/snomedct/189954007, http://identifiers.org/snomedct/12169001

comment

Editor note: MESH considers this a myoblastoma but we go with NCIT which states nerve sheath origin, consistent with GARD definition; also check ONCOTREE placement

exactMatch

http://identifiers.org/mesh/C535558, http://linkedlifedata.com/resource/umls/id/C0085167, http://purl.obolibrary.org/obo/NCIT_C3474, http://identifiers.org/mesh/D016586, http://purl.obolibrary.org/obo/DOID_2411, http://identifiers.org/snomedct/404035005

has narrow synonym

neoplasm of granular cell, granular cell tumor NOS (morphologic abnormality)

has related synonym

malignant variant of Abrikosov's tumor, Abrikosoff's granulous cell tumor, giant granulocellular Abrikosov's tumor, Abrikosoff's tumor, Abrikosov's tumor, GCT, Abrikosov’s tumor

id

EFO:1000284

see also

https://rarediseases.info.nih.gov/diseases/9618/granular-cell-tumor