Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. [ ]

Synonyms: Cryoimmunoglobulinaemia cryoglobulin-related vasculitis cryoglobulinemia

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Term information

database cross reference
  • DOID:2917 (MONDO:equivalentTo)
  • NCIt:C26736
  • UMLS:C0010403 (NCIT:C26736)
  • ICD9:273.2 (i2s)
  • MeSH:D003449
  • MONDO:0005576
  • MedDRA:10011475
  • ICD10:D89.1 (MONDO:equivalentTo)
  • MESH:D003449 (MONDO:equivalentTo)
  • GARD:0006217 (MONDO:equivalentTo)
  • SNOMEDCT:30911005
  • NCIT:C26736 (MONDO:equivalentTo)
  • SCTID:30911005 (MONDO:equivalentTo)
  • COHD:4149583 (MONDO:equivalentTo)



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see also

term editor

Dani Welter