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multiple sclerosis

^ http://www.ebi.ac.uk/efo/EFO_0003885


An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Synonyms: Disseminated Sclerosis, Multiple Sclerosis, Acute Fulminating, MULTIPLE SCLEROSIS ACUTE FULMINATING, MS, Sclerosis, Multiple, MS (Multiple Sclerosis), Sclerosis, Disseminated

Term info

OMIM definition citation

OMIM:612595, OMIM:614810, OMIM:126200

SNOMEDCT definition citation

SNOMEDCT:24700007

bioportal provenance

Disseminated Sclerosis[accessedResource: MSH:D009103][accessDate: 05-04-2011], MULTIPLE SCLEROSIS ACUTE FULMINATING[accessedResource: MSH:D009103][accessDate: 05-04-2011], MS (Multiple Sclerosis)[accessedResource: MSH:D009103][accessDate: 05-04-2011], MS[accessedResource: MSH:D009103][accessDate: 05-04-2011], Sclerosis, Multiple[accessedResource: MSH:D009103][accessDate: 05-04-2011], Sclerosis, Disseminated[accessedResource: MSH:D009103][accessDate: 05-04-2011], Multiple Sclerosis, Acute Fulminating[accessedResource: MSH:D009103][accessDate: 05-04-2011], An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)[accessedResource: MSH:D009103][accessDate: 05-04-2011]

gwas trait

true

term editor

Tomasz Adamusiak