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medulloblastoma

^ http://www.ebi.ac.uk/efo/EFO_0002939


A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)

A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, desmoplastic medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity and advanced neuronal differentiation. (from NCI Thesuarus)

Synonyms: Medulloblastoma, Childhood, Medullomyoblastoma, Medulloblastoma, Adult, Medulloblastoma, Melanocytic, Sarcoma, Cerebellar, Circumscribed Arachnoidal, Medulloblastoma, Desmoplastic, Childhood Medulloblastoma, Arachnoidal Cerebellar Sarcoma, Circumscribed, Medulloblastomas, Desmoplastic, Medullomyoblastomas, Medulloblastomas, Childhood, Adult Medulloblastomas, Adult Medulloblastoma, Melanocytic Medulloblastomas, Desmoplastic Medulloblastomas, Childhood Medulloblastomas, Medulloblastomas, Melanocytic, Medulloblastomas, Adult, Melanocytic Medulloblastoma, Medulloblastomas, Desmoplastic Medulloblastoma

Term info

SNOMEDCT definition citation

SNOMEDCT:443333004, SNOMEDCT:83217000

bioportal provenance

Sarcoma, Cerebellar, Circumscribed Arachnoidal[accessedResource: MSH:D008527][accessDate: 05-04-2011], Desmoplastic Medulloblastomas[accessedResource: MSH:D008527][accessDate: 05-04-2011], Childhood Medulloblastoma[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastoma, Desmoplastic[accessedResource: MSH:D008527][accessDate: 05-04-2011], Adult Medulloblastomas[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medullomyoblastomas[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medullomyoblastoma[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastomas, Melanocytic[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastomas, Desmoplastic[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastomas, Childhood[accessedResource: MSH:D008527][accessDate: 05-04-2011], Desmoplastic Medulloblastoma[accessedResource: MSH:D008527][accessDate: 05-04-2011], Melanocytic Medulloblastomas[accessedResource: MSH:D008527][accessDate: 05-04-2011], Adult Medulloblastoma[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastoma, Childhood[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastomas[accessedResource: MSH:D008527][accessDate: 05-04-2011], Childhood Medulloblastomas[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastoma, Melanocytic[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastoma, Adult[accessedResource: MSH:D008527][accessDate: 05-04-2011], Arachnoidal Cerebellar Sarcoma, Circumscribed[accessedResource: MSH:D008527][accessDate: 05-04-2011], A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)[accessedResource: MSH:D008527][accessDate: 05-04-2011], Medulloblastomas, Adult[accessedResource: MSH:D008527][accessDate: 05-04-2011], Melanocytic Medulloblastoma[accessedResource: MSH:D008527][accessDate: 05-04-2011]

term editor

Tomasz Adamusiak