JSON

ischemia reperfusion injury

^ http://www.ebi.ac.uk/efo/EFO_0002687


Some of the known risk factors for cardiovascular disease (hypercholesterolaemia, hypertension, and diabetes) appear to exaggerate many of the microvascular alterations elicited by ischaemia and reperfusion (I/R). The inflammatory mediators released as a consequence of reperfusion also appear to activate endothelial cells in remote organs that are not exposed to the initial ischaemic insult. This distant response to I/R can result in leukocyte-dependent microvascular injury that is characteristic of the multiple organ dysfunction syndrome. Adaptational responses to I/R injury have been demonstrated that allow for protection of briefly ischaemic tissues against the harmful effects of subsequent, prolonged ischaemia, a phenomenon called ischaemic preconditioning.

Synonyms: myocardial reperfusion injury, ischaemia reperfusion injury

Term info

MedDRA definition citation

MedDRA:10051624

PMID definition citation

PMID:10685060

term editor

Sirarat Sarntivijai

Term relations