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macroglobulinemia

^ http://www.ebi.ac.uk/efo/EFO_0002616


Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is a Plasma cell dyscrasia, resembling leukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete a monoclonal immunoglobulin M component. There is diffuse infiltration by the malignant cells of the bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin can produce symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence of macroglobulinemia is in the sixth and seventh decades of life.

Synonyms: Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia, Waldenstrom's macroglobulinemia (disorder), primary macroglobulinemia, Waldenstrom's macroglobulinemia, Lymphoplasmacytic Lymphoma, Macroglobulinemia NOS (disorder), Macroglobulinemia (disorder), Waldenstrom's macroglobulinaemia, Waldenstrom's macroglobulinemia (morphologic abnormality), Waldenstrom's macroglob'naemia, Waldenstrm macroglobulinemia (disorder)

Term info

SNOMEDCT definition citation

SNOMEDCT:190817009

Wikipedia definition citation

Wikipedia:Macroglobulinemia

bioportal provenance

Waldenstrom's macroglob'naemia[accessedResource: DOID:9080][accessDate: 05-04-2011], Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia[accessedResource: DOID:9080][accessDate: 05-04-2011], Waldenstrom's macroglobulinemia (disorder)[accessedResource: DOID:9080][accessDate: 05-04-2011], Macroglobulinemia NOS (disorder)[accessedResource: DOID:9080][accessDate: 05-04-2011], primary macroglobulinemia[accessedResource: DOID:9080][accessDate: 05-04-2011], Waldenstrom's macroglobulinemia (morphologic abnormality)[accessedResource: DOID:9080][accessDate: 05-04-2011], Macroglobulinemia (disorder)[accessedResource: DOID:9080][accessDate: 05-04-2011], Waldenstrom's macroglobulinaemia[accessedResource: DOID:9080][accessDate: 05-04-2011], Waldenstrm macroglobulinemia (disorder)[accessedResource: DOID:9080][accessDate: 05-04-2011]

term editor

Sirarat Sarntivijai, Ele Holloway, Tomasz Adamusiak

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