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Parkinson's disease

^ http://www.ebi.ac.uk/efo/EFO_0002508


A neurodegenerative disease that results_from degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Synonyms: Parkinson's syndrome, Parkinsons, Primary Parkinsonism, Parkinsons disease, Parkinson disease, Parkinson's disease (disorder), Parkinson's disease NOS, Parkinson Disease, Idiopathic, PARKINSON DIS, Paralysis agitans, IDIOPATHIC PARKINSONS DIS, PARKINSON DIS IDIOPATHIC, Parkinsonism, Primary, Parkinson's Disease, Lewy Body, IDIOPATHIC PARKINSON DIS, Idiopathic PD, Idiopathic Parkinson Disease, Lewy Body Parkinson's Disease, Parkinsonian disorder, LEWY BODY PARKINSON DIS, Parkinson's, Idiopathic Parkinson's Disease, Parkinson's disease NOS (disorder), Lewy Body Parkinson Disease, PARKINSONS DIS IDIOPATHIC, PARKINSONS DIS, Parkinson's Disease, Idiopathic, Parkinson syndrome, PARKINSONS DIS LEWY BODY

Term info

NIFSTD definition citation

NIFSTD:birnlex_2098

OMIM definition citation

OMIM:616710, OMIM:616361, OMIM:168600

SNOMEDCT definition citation

SNOMEDCT:49049000

bioportal provenance

Parkinson syndrome[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], Parkinsons[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], Parkinson's Disease, Lewy Body[accessedResource: MSH:D010300][accessDate: 05-04-2011], IDIOPATHIC PARKINSONS DIS[accessedResource: MSH:D010300][accessDate: 05-04-2011], Primary Parkinsonism[accessedResource: MSH:D010300][accessDate: 05-04-2011], Parkinson disease[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], Parkinson's disease NOS[accessedResource: DOID:14330][accessDate: 05-04-2011], PARKINSON DIS IDIOPATHIC[accessedResource: MSH:D010300][accessDate: 05-04-2011], PARKINSONS DIS[accessedResource: MSH:D010300][accessDate: 05-04-2011], Parkinson's syndrome[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], Parkinson's disease (disorder)[accessedResource: DOID:14330][accessDate: 05-04-2011], Parkinsons disease[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)[accessedResource: MSH:D010300][accessDate: 05-04-2011], Parkinson's[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], IDIOPATHIC PARKINSON DIS[accessedResource: MSH:D010300][accessDate: 05-04-2011], Parkinson's disease NOS (disorder)[accessedResource: DOID:14330][accessDate: 05-04-2011], Parkinsonian disorder[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], PARKINSONS DIS LEWY BODY[accessedResource: MSH:D010300][accessDate: 05-04-2011], A neurodegenerative disease that results_from degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.[accessedResource: DOID:14330][accessDate: 05-04-2011], PARKINSON DIS[accessedResource: MSH:D010300][accessDate: 05-04-2011], LEWY BODY PARKINSON DIS[accessedResource: MSH:D010300][accessDate: 05-04-2011], Paralysis Agitans[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], Idiopathic Parkinson's Disease[accessedResource: MSH:D010300][accessDate: 05-04-2011], Parkinson Disease, Idiopathic[accessedResource: MSH:D010300][accessDate: 05-04-2011], Lewy Body Parkinson's Disease[accessedResource: MSH:D010300][accessDate: 05-04-2011], Idiopathic Parkinson Disease[accessedResource: MSH:D010300][accessDate: 05-04-2011], Lewy Body Parkinson Disease[accessedResource: MSH:D010300][accessDate: 05-04-2011], PARKINSONS DIS IDIOPATHIC[accessedResource: MSH:D010300][accessDate: 05-04-2011], Parkinsonism, Primary[accessedResource: MSH:D010300][accessDate: 05-04-2011], Idiopathic PD[accessedResource: NIFSTD:birnlex_2098][accessDate: 05-04-2011], Parkinson's Disease, Idiopathic[accessedResource: MSH:D010300][accessDate: 05-04-2011]

gwas trait

true

term editor

Ele Holloway, James Malone, Tomasz Adamusiak