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systemic scleroderma

^ http://www.ebi.ac.uk/efo/EFO_0000717


A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.

Synonyms: Scleroderma (& [systemic sclerosis]), PSS - Progressive systemic sclerosis, Systemic sclerosis, Scleroderma, Systemic, PSS (progressive systemic sclerosis), Sclerosis, Systemic, SS - Systemic sclerosis, Scleroderma syndrome, Progressive systemic sclerosis, Systemic sclerosis (disorder), Scleroderma, Thibierge-Weissenbach syndrome

Term info

SNOMEDCT definition citation

SNOMEDCT:89155008, SNOMEDCT:444133002

bioportal provenance

A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.[accessedResource: DOID:418][accessDate: 05-04-2011], Scleroderma[accessedResource: DOID:418][accessDate: 05-04-2011], Scleroderma syndrome[accessedResource: SNOMEDCT:89155008][accessDate: 05-04-2011], SS - Systemic sclerosis[accessedResource: SNOMEDCT:89155008][accessDate: 05-04-2011], Thibierge-Weissenbach syndrome[accessedResource: SNOMEDCT:89155008][accessDate: 05-04-2011], PSS (progressive systemic sclerosis)[accessedResource: DOID:418][accessDate: 05-04-2011], Sclerosis, Systemic[accessedResource: MSH:D012595][accessDate: 05-04-2011], Scleroderma (& [systemic sclerosis])[accessedResource: DOID:418][accessDate: 05-04-2011], Progressive systemic sclerosis[accessedResource: SNOMEDCT:89155008][accessDate: 05-04-2011], Systemic Sclerosis[accessedResource: MSH:D012595][accessDate: 05-04-2011], Scleroderma, Systemic[accessedResource: MSH:D012595][accessDate: 05-04-2011], Systemic sclerosis (disorder)[accessedResource: SNOMEDCT:89155008][accessDate: 05-04-2011], PSS - Progressive systemic sclerosis[accessedResource: SNOMEDCT:89155008][accessDate: 05-04-2011], A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.[accessedResource: MSH:D012595][accessDate: 05-04-2011]

gwas trait

true

term editor

Gautier Koscielny, James Malone