Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. [ http://www.ncbi.nlm.nih.gov/pubmed/32903387 ]

Synonyms: [M]Neuroblastoma NOS (morphologic abnormality) neuroblastoma Neuroblastomas [M]Neuroblastoma NOS neural Crest tumor, malignant neuroblastoma, malignant Central neuroblastoma (neuroblastoma NOS) or (sympathicoblastoma) NB - Neuroblastoma neuroblastoma (Schwannian Stroma-poor) neuroblastoma (Schwannian Stroma-Poor) Neuroblastoma, NOS neuroblastoma (morphologic abnormality) Sympathicoblastoma neuroblastoma NOS (morphologic abnormality)

This is just here as a test because I lose it

Term information

database cross reference
  • SNOMEDCT:432328008
  • GARD:0007185 (MONDO:equivalentTo)
  • SCTID:432328008 (MONDO:equivalentTo)
  • MONDO:0005072
  • ICD10:C74.9 (Orphanet:635)
  • OMIM:256700
  • NIFSTD:birnlex_12631 (EFO:0000621)
  • MESH:D009447 (Orphanet:635)
  • DOID:769 (MONDO:equivalentTo)
  • SNOMEDCT:87364003
  • OMIM:613013
  • MedDRA:10029260 (Orphanet:635)
  • UMLS:CN205405 (MONDO:equivalentTo)
  • ONCOTREE:NBL (MONDO:equivalentTo)
  • UMLS:C0027819 (Orphanet:635)
  • OMIM:613014
  • ICDO:9500/3 (NCIT:C3270)
  • NCIt:C3270
  • MeSH:D009447
  • NCIT:C3270 (MONDO:equivalentTo)
  • Orphanet:635 (MONDO:equivalentTo)
Subsets

gard_rare, ordo_disease

closeMatch

http://identifiers.org/snomedct/189931003

http://identifiers.org/snomedct/269507008

http://identifiers.org/snomedct/87364003

comment

NB is a disease of the sympaticoadrenal lineage of the neural crest, with tumors forming anywhere in the sympathetic nervous system. The tumors most commonly arise in the abdomen (65%), however, they also occur in the neck, chest, and pelvis. Approximately 50% of patients present with evidence of metastasis. Frequent metastasis sites include cortical bone, bone marrow, liver, and lymph nodes. The most common genetic change is MYCN amplification, which occurs in approximately 20% of patients, and is strongly correlated with advanced stage NB. Additionally, deletions of the short arm of chromosome 1 (1p) are found in 25–35% of patients and can be correlated with MYCN amplification. Outside of MYC linked changes, allelic loss of 11q is present in 35–45% of patients and is also associated with high-risk disease features.

exactMatch

http://purl.obolibrary.org/obo/DOID_769

http://identifiers.org/mesh/C536408

http://linkedlifedata.com/resource/umls/id/CN205405

http://linkedlifedata.com/resource/umls/id/C2931189

http://identifiers.org/mesh/D009447

http://linkedlifedata.com/resource/umls/id/C0027819

http://identifiers.org/meddra/10029260

http://purl.obolibrary.org/obo/NCIT_C3270

http://purl.obolibrary.org/obo/Orphanet_635

http://identifiers.org/snomedct/432328008

excluded subClassOf

http://purl.obolibrary.org/obo/MONDO_0016713

http://purl.obolibrary.org/obo/MONDO_0002366

gwas trait

true

id

EFO:0000621

see also

https://rarediseases.info.nih.gov/diseases/7185/neuroblastoma

term editor

Tomasz Adamusiak

James Malone