Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. [ ]

Synonyms: [M]Neuroblastoma NOS (morphologic abnormality) neuroblastoma Neuroblastomas [M]Neuroblastoma NOS neural Crest tumor, malignant neuroblastoma, malignant Central neuroblastoma (neuroblastoma NOS) or (sympathicoblastoma) NB - Neuroblastoma neuroblastoma (Schwannian Stroma-poor) neuroblastoma (Schwannian Stroma-Poor) Neuroblastoma, NOS neuroblastoma (morphologic abnormality) Sympathicoblastoma neuroblastoma NOS (morphologic abnormality)

This is just here as a test because I lose it

Term information

database cross reference
  • SNOMEDCT:432328008
  • GARD:0007185 (MONDO:equivalentTo)
  • SCTID:432328008 (MONDO:equivalentTo)
  • MONDO:0005072
  • ICD10:C74.9 (Orphanet:635)
  • OMIM:256700
  • NIFSTD:birnlex_12631 (EFO:0000621)
  • MESH:D009447 (Orphanet:635)
  • DOID:769 (MONDO:equivalentTo)
  • SNOMEDCT:87364003
  • OMIM:613013
  • MedDRA:10029260 (Orphanet:635)
  • UMLS:CN205405 (MONDO:equivalentTo)
  • ONCOTREE:NBL (MONDO:equivalentTo)
  • UMLS:C0027819 (Orphanet:635)
  • OMIM:613014
  • ICDO:9500/3 (NCIT:C3270)
  • NCIt:C3270
  • MeSH:D009447
  • NCIT:C3270 (MONDO:equivalentTo)
  • Orphanet:635 (MONDO:equivalentTo)

gard_rare, ordo_disease



NB is a disease of the sympaticoadrenal lineage of the neural crest, with tumors forming anywhere in the sympathetic nervous system. The tumors most commonly arise in the abdomen (65%), however, they also occur in the neck, chest, and pelvis. Approximately 50% of patients present with evidence of metastasis. Frequent metastasis sites include cortical bone, bone marrow, liver, and lymph nodes. The most common genetic change is MYCN amplification, which occurs in approximately 20% of patients, and is strongly correlated with advanced stage NB. Additionally, deletions of the short arm of chromosome 1 (1p) are found in 25–35% of patients and can be correlated with MYCN amplification. Outside of MYC linked changes, allelic loss of 11q is present in 35–45% of patients and is also associated with high-risk disease features.


excluded subClassOf

gwas trait




see also

term editor

Tomasz Adamusiak

James Malone