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glioblastoma multiforme

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The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO)

A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures (MeSH).

Synonyms: Glioblastoma, Giant Cell, Grade IV Astrocytic Neoplasm, Glioblastoma (morphologic abnormality), Spongioblastoma Multiforme, Glioblastoma, Grade IV Astrocytomas, Glioblastoma, no ICD-O subtype (morphologic abnormality), Glioblastoma, no ICD-O subtype, Grade IV Astrocytic Tumor, Glioblastomas, GBM, Glioblastoma, NOS, Glioblastomas, Giant Cell, GLM - Glioblastoma multiforme, Astrocytomas, Grade IV, Grade IV Astrocytoma, [M]Glioblastoma NOS, Glioblastoma NOS (morphologic abnormality), GBM - Glioblastoma multiforme, [M]Glioblastoma NOS (morphologic abnormality), Giant Cell Glioblastomas, Giant Cell Glioblastoma, GBM (Glioblastoma), Astrocytoma, Grade IV

Term info

NIFSTD definition citation

NIFSTD:birnlex_12620

SNOMEDCT definition citation

SNOMEDCT:393563007

bioportal provenance

GBM - Glioblastoma multiforme[accessedResource: SNOMEDCT:63634009][accessDate: 05-04-2011], grade IV astrocytoma[accessedResource: NCIt:C3058][accessDate: 05-04-2011], Giant Cell Glioblastoma[accessedResource: MSH:D005909][accessDate: 05-04-2011], Giant Cell Glioblastomas[accessedResource: MSH:D005909][accessDate: 05-04-2011], Spongioblastoma Multiforme[accessedResource: NCIt:C3058][accessDate: 05-04-2011], Glioblastomas, Giant Cell[accessedResource: MSH:D005909][accessDate: 05-04-2011], GLM - Glioblastoma multiforme[accessedResource: SNOMEDCT:63634009][accessDate: 05-04-2011], [M]Glioblastoma NOS[accessedResource: SNOMEDCT:269506004][accessDate: 05-04-2011], Astrocytoma, Grade IV[accessedResource: NIFSTD:birnlex_12620][accessDate: 05-04-2011], Grade IV Astrocytic Tumor[accessedResource: NCIt:C3058][accessDate: 05-04-2011], Glioblastoma, NOS[accessedResource: SNOMEDCT:63634009][accessDate: 05-04-2011], Grade IV Astrocytic Neoplasm[accessedResource: NCIt:C3058][accessDate: 05-04-2011], Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus (MeSH).[accessedResource: NIFSTD:birnlex_12621][accessDate: 05-04-2011], Glioblastoma (morphologic abnormality)[accessedResource: SNOMEDCT:63634009][accessDate: 05-04-2011], Glioblastomas[accessedResource: MSH:D005909][accessDate: 05-04-2011], Glioblastoma, Giant Cell[accessedResource: MSH:D005909][accessDate: 05-04-2011], Glioblastoma[accessedResource: NIFSTD:birnlex_12620][accessDate: 05-04-2011], A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.[accessedResource: MSH:D005909][accessDate: 05-04-2011], GBM[accessedResource: NCIt:C3058][accessDate: 05-04-2011], Astrocytomas, Grade IV[accessedResource: MSH:D005909][accessDate: 05-04-2011], Optic Nerve Glioma[accessedResource: NIFSTD:birnlex_12621][accessDate: 05-04-2011], The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO)[accessedResource: NCIt:C3058][accessDate: 05-04-2011], Glioblastoma, no ICD-O subtype (morphologic abnormality)[accessedResource: SNOMEDCT:63634009][accessDate: 05-04-2011], Glioblastoma NOS (morphologic abnormality)[accessedResource: DOID:3068][accessDate: 05-04-2011], GBM (Glioblastoma)[accessedResource: NCIt:C3058][accessDate: 05-04-2011], A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures (MeSH).[accessedResource: NIFSTD:birnlex_12620][accessDate: 05-04-2011], Optic Glioma[accessedResource: NIFSTD:birnlex_12621][accessDate: 05-04-2011], [M]Glioblastoma NOS (morphologic abnormality)[accessedResource: SNOMEDCT:269506004][accessDate: 05-04-2011], Malignant Optic Nerve Astrocytoma[accessedResource: NIFSTD:birnlex_12621][accessDate: 05-04-2011], Glioblastoma, no ICD-O subtype[accessedResource: SNOMEDCT:63634009][accessDate: 05-04-2011], Grade IV Astrocytomas[accessedResource: MSH:D005909][accessDate: 05-04-2011]

term editor

Tomasz Adamusiak, James Malone