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chronic myelogenous leukemia

Go to external page http://www.ebi.ac.uk/efo/EFO_0000339

A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. [ NCIT : C3174 ]

Synonyms:

chronic myelogenous leukemia (CML)

chronic myelogenous leukemia, BCR-ABL1 positive

chronic myelogenous leukemia

chronic myeloid leukemia

chronic granulocytic leukemia

leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation

leukemia, chronic myeloid, Philadelphia chromosome positive, somatic

chronic myelocytic leukemia

BCR-ABL Positive chronic myelogenous leukemia

chronic myelogenous leukemia, BCR-ABL1 Positive

CML

chronic myelogenous leukemias

hematopoeitic - chronic myelocytic leukemia (CML)

myeloid leukemia, chronic

CML - chronic myelogenous leukemia

This is just here as a test because I lose it

Term information

database cross reference
  • GARD:0006105 (MONDO:equivalentTo)
  • ICD10:C92.1 (Orphanet:521)
  • MedDRA:10009013 (Orphanet:521)
  • OMIM:608232 (Orphanet:521/e)
  • UMLS:C0023473 (Orphanet:521/e)
  • UMLS:C0023473 (Orphanet:521)
  • DOID:8552 (MONDO:equivalentTo)
  • ICDO:9875/3 (NCIT:C3174)
  • OMIM:608232 (Orphanet:521)
  • ICDO:9863/3 (NCIT:C3174)
  • COHD:134603 (MONDO:equivalentTo)
  • MONDO:0011996
  • EFO:0000339 (MONDO:equivalentTo)
  • ONCOTREE:CML (MONDO:equivalentTo)
  • KEGG:05220 (MONDO:relatedTo)
  • NCIT:C3174 (MONDO:equivalentTo)
  • Orphanet:521 (OMIM:608232)
  • NCIT:C3177 (MONDO:directSiblingOf)
  • MedDRA:10009013 (Orphanet:521/e)
  • GARD:0006105 (Orphanet-shared)
  • ICD9:205.1 (EFO:0000339)
Subsets

ordo_disease

IAO 0000233
  • https://github.com/monarch-initiative/mondo/issues/4521
closeMatch
  • http://identifiers.org/meddra/10009013
exactMatch
  • http://purl.obolibrary.org/obo/DOID_8552
  • http://purl.obolibrary.org/obo/Orphanet_521
  • http://linkedlifedata.com/resource/umls/id/C0023473
  • https://omim.org/entry/608232
  • http://purl.obolibrary.org/obo/NCIT_C3174
gwas trait
  • true
has related synonym
  • leukemia, chronic myelogenous
  • leukemia, chronic myeloid
  • leukemia, chronic myeloid, atypical
id
  • EFO:0000339