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acute promyelocytic leukemia

^ http://www.ebi.ac.uk/efo/EFO_0000224


Acute promyelocytic leukemia (APL) is an aggressive form of acute myeloid leukemia (AML; see this term), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue. [ Orphanet:520 ]

Synonyms: Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA, Promyelocytic Leukemia, AML with t(15;17)(q22;q12), APML - acute promyelocytic leukemia, APML - Acute promyelocytic leukemia, AML with t(15;17)(q22;q12);(PML/RARalpha) and variants, acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants, acute promyelocytic leukemia with PML-rara, AML M3, acute myeloblastic leukemia 3, acute promyelocytic leukemia with t(15;17)(q22;q12); PML/rara, acute promyelocytic leukemia with t(15;17)(q22;q12); PML-rara, APML, acute promyelocytic leukemia, promyelocytic leukemia, FAB M3, acute myeloblastic leukemia type 3, APL, acute myeloid leukemia M3

Term info

database cross reference
  • SCTID:110004001 (MONDO:kboom-pr-0.76/0.38/0.67)
  • OMIM:612376 (Orphanet:520)
  • UMLS:C0023487 (Orphanet:520)
  • Orphanet:520 (OMIM:612376)
  • SNOMEDCT:28950004
  • ICD10:C92.40 (DOID:0060318)
  • NCIt:C3182
  • GARD:0000538 (Orphanet-shared)
  • DOID:0060318 (MONDO:equivalentTo)
  • NCIT:C3182 (MONDO:kboom-pr-0.94/0.83/0.97)
  • ICD10:C92.4 (Orphanet:520)
  • MESH:D015473 (Orphanet:520)
  • ICDO:9866/3 (NCIT:C3182)
  • MedDRA:10001019 (Orphanet:520)
  • MONDO:0012883
Subsets

ordo_disease

closeMatch

http://identifiers.org/snomedct/28950004

exactMatch

http://identifiers.org/snomedct/110004001, http://purl.obolibrary.org/obo/DOID_0060318, http://purl.obolibrary.org/obo/Orphanet_520, http://identifiers.org/meddra/10001019, http://identifiers.org/omim/612376, http://identifiers.org/mesh/D015473, http://purl.obolibrary.org/obo/NCIT_C3182, http://linkedlifedata.com/resource/umls/id/C0023487

has related synonym

acute promyelocytic leukemia; APL, leukemia, acute promyelocytic, APL

id

EFO:0000224

term editor

Tomasz Adamusiak