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acute promyelocytic leukemia

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An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are two variants: the typical and microgranular variant. This AML is particularly sensitive to treatment with all trans-retinoic acid and has a favorable prognosis. (WHO, 2001)

An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are two variants: the typical and micro granular (hypo granular) variant. This AML is particularly sensitive to treatment with all trans-retinoic acid and has a favorable prognosis. (WHO, 2001) -- 2003

Synonyms: APML, Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA, Promyelocytic Leukemia, AML with t(15;17)(q22;q12), APML - Acute promyelocytic leukemia, FAB M3, APL

Term info

SNOMEDCT definition citation

SNOMEDCT:28950004

bioportal provenance

APL[accessedResource: NCIt:C3182][accessDate: 05-04-2011], FAB M3[accessedResource: NCIt:C3182][accessDate: 05-04-2011], Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML/RARA[accessedResource: NCIt:C3182][accessDate: 05-04-2011], APML - Acute promyelocytic leukemia[accessedResource: NCIt:C3182][accessDate: 05-04-2011], Promyelocytic Leukemia[accessedResource: NCIt:C3182][accessDate: 05-04-2011], An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are two variants: the typical and microgranular variant. This AML is particularly sensitive to treatment with all trans-retinoic acid and has a favorable prognosis. (WHO, 2001)[accessedResource: NCIt:C3182][accessDate: 05-04-2011], Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA[accessedResource: NCIt:C3182][accessDate: 05-04-2011], AML with t(15;17)(q22;q12)[accessedResource: NCIt:C3182][accessDate: 05-04-2011], APML[accessedResource: NCIt:C3182][accessDate: 05-04-2011]

term editor

Tomasz Adamusiak

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