JSON

hepatocellular carcinoma

^ http://www.ebi.ac.uk/efo/EFO_0000182


A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.

Tumors or cancer of the LIVER.

A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. --2002

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Synonyms: Cancers, Adult Liver, Hepatic Cancer, NEOPL LIVER, Neoplasms, Liver, Hepatic Cancers, Neoplasm, Hepatic, Adult Liver Cancers, Liver Cancer, Cancer, Liver, Hepatoma, Primary Carcinoma of the Liver Cells, Liver Neoplasms, Cancers, Hepatocellular, Cancer of Liver, Liver Cancers, Cancer, Hepatic, Hepatic Neoplasms, Neoplasm, Liver, Cancers, Hepatic, Hepatomas, Hepatic Neoplasm, NEOPL HEPATIC, Liver Cell Carcinoma, Primary Carcinoma of Liver Cells, Carcinoma of the Liver Cells, HEPATIC NEOPL, Cancer, Hepatocellular, Cancers, Liver, Liver Cancer, Adult, Cancer, Adult Liver, Liver Cell Cancer (Hepatocellular Carcinoma), HCC, Liver Neoplasm, Hepatocellular Cancers, LIVER NEOPL, Liver Cell Carcinoma, Adult, Adult Liver Cancer, Neoplasms, Hepatic, Cancer of the Liver, Hepatocellular Carcinomas, Liver Cancers, Adult, Hepatocellular Cancer, Carcinomas, Hepatocellular, Carcinoma, Hepatocellular, Carcinoma of Liver Cells

Term info

SNOMEDCT definition citation

SNOMEDCT:25370001

bioportal provenance

Liver Cell Carcinoma[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Liver Cancers, Adult[accessedResource: MSH:D006528][accessDate: 05-04-2011], Hepatic Cancers[accessedResource: MSH:D008113][accessDate: 05-04-2011], Liver Cancers[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancer, Adult Liver[accessedResource: MSH:D006528][accessDate: 05-04-2011], Cancers, Adult Liver[accessedResource: MSH:D006528][accessDate: 05-04-2011], Hepatocellular Carcinomas[accessedResource: MSH:D006528][accessDate: 05-04-2011], Liver Cancer, Adult[accessedResource: MSH:D006528][accessDate: 05-04-2011], Hepatic Neoplasm[accessedResource: MSH:D008113][accessDate: 05-04-2011], NEOPL LIVER[accessedResource: MSH:D008113][accessDate: 05-04-2011], HCC[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Cancer of the Liver[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancer, Liver[accessedResource: MSH:D008113][accessDate: 05-04-2011], Hepatocellular Cancer[accessedResource: MSH:D006528][accessDate: 05-04-2011], Adult Liver Cancer[accessedResource: MSH:D006528][accessDate: 05-04-2011], Carcinomas, Hepatocellular[accessedResource: MSH:D006528][accessDate: 05-04-2011], A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Neoplasm, Liver[accessedResource: MSH:D008113][accessDate: 05-04-2011], Hepatic Cancer[accessedResource: MSH:D008113][accessDate: 05-04-2011], Liver Cell Cancer (Hepatocellular Carcinoma)[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Liver Cell Carcinoma, Adult[accessedResource: MSH:D006528][accessDate: 05-04-2011], Liver Neoplasm[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancers, Hepatocellular[accessedResource: MSH:D006528][accessDate: 05-04-2011], Carcinoma of Liver Cells[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Neoplasms, Hepatic[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancer of Liver[accessedResource: MSH:D008113][accessDate: 05-04-2011], Primary Carcinoma of the Liver Cells[accessedResource: NCIt:C3099][accessDate: 05-04-2011], HEPATIC NEOPL[accessedResource: MSH:D008113][accessDate: 05-04-2011], Hepatocellular Cancers[accessedResource: MSH:D006528][accessDate: 05-04-2011], Liver Neoplasms[accessedResource: MSH:D008113][accessDate: 05-04-2011], Liver Cancer[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancers, Liver[accessedResource: MSH:D008113][accessDate: 05-04-2011], Neoplasm, Hepatic[accessedResource: MSH:D008113][accessDate: 05-04-2011], Carcinoma, Hepatocellular[accessedResource: MSH:D006528][accessDate: 05-04-2011], Primary Carcinoma of Liver Cells[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Adult Liver Cancers[accessedResource: MSH:D006528][accessDate: 05-04-2011], LIVER NEOPL[accessedResource: MSH:D008113][accessDate: 05-04-2011], Hepatic Neoplasms[accessedResource: MSH:D008113][accessDate: 05-04-2011], Hepatoma[accessedResource: NCIt:C3099][accessDate: 05-04-2011], A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.[accessedResource: MSH:D006528][accessDate: 05-04-2011], Cancer, Hepatocellular[accessedResource: MSH:D006528][accessDate: 05-04-2011], NEOPL HEPATIC[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancer, Hepatic[accessedResource: MSH:D008113][accessDate: 05-04-2011], Carcinoma of the Liver Cells[accessedResource: NCIt:C3099][accessDate: 05-04-2011], Hepatomas[accessedResource: MSH:D006528][accessDate: 05-04-2011], Tumors or cancer of the LIVER.[accessedResource: MSH:D008113][accessDate: 05-04-2011], Neoplasms, Liver[accessedResource: MSH:D008113][accessDate: 05-04-2011], Cancers, Hepatic[accessedResource: MSH:D008113][accessDate: 05-04-2011]

gwas trait

true

term editor

James Malone, Tomasz Adamusiak