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Ewing sarcoma

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A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.

A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.

A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. (From Dorland, 27th ed; Stedman, 25th ed)

A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms. -- 2004

Synonyms: Sarcoma, Ewing, Ewing's Family of Tumors, Tumors of Ewing's Family, peripheral neuroectodermal tumor (morphologic abnormality), Ewings sarcoma-primitive neuroectodermal tumor, peripheral neuroepithelioma (disorder), Ewings sarcoma, Ewing sarcoma family of tumors, Ewing Tumor, Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Sarcoma, Ewings, Ewing Family of Tumors, peripheral Neuroectodermal neoplasm, Sarcoma, Ewing's, Ewing's Family of Tumours, EFTs, PNET of Thoracopulmonary Region, Ewing's Sarcoma, Ewing's tumour, peripheral neuroectodermal tumor (disorder), ES, Ewing's sarcoma (morphologic abnormality), Tumors of the Ewing's Family, Tumor, Ewing's, Ewing's tumor, extraosseous Ewing's sarcoma, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, bone Ewing's sarcoma, Ewings Tumor

Term info

SNOMEDCT definition citation

SNOMEDCT:76909002

bioportal provenance

PNET of Thoracopulmonary Region[accessedResource: DOID:3369][accessDate: 05-04-2011], Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor[accessedResource: NCIt:C27291][accessDate: 05-04-2011], peripheral neuroepithelioma (disorder)[accessedResource: DOID:3369][accessDate: 05-04-2011], peripheral neuroectodermal tumor (disorder)[accessedResource: DOID:3369][accessDate: 05-04-2011], peripheral Neuroectodermal neoplasm[accessedResource: DOID:3369][accessDate: 05-04-2011], Ewings Tumor[accessedResource: MSH:D012512][accessDate: 05-04-2011], Ewings sarcoma-primitive neuroectodermal tumor[accessedResource: DOID:3369][accessDate: 05-04-2011], ES[accessedResource: NCIt:C4817][accessDate: 05-04-2011], Ewings sarcoma[accessedResource: DOID:3369][accessDate: 05-04-2011], EFTs[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Ewing Family of Tumors[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Sarcoma, Ewing[accessedResource: MSH:D012512][accessDate: 05-04-2011], Ewing Tumor[accessedResource: MSH:D012512][accessDate: 05-04-2011], Tumor, Ewing's[accessedResource: MSH:D012512][accessDate: 05-04-2011], Sarcoma, Ewing's[accessedResource: MSH:D012512][accessDate: 05-04-2011], Askin's tumor (morphologic abnormality)[accessedResource: DOID:3369][accessDate: 05-04-2011], peripheral neuroectodermal tumor (morphologic abnormality)[accessedResource: DOID:3369][accessDate: 05-04-2011], Ewing's sarcoma (morphologic abnormality)[accessedResource: DOID:3369][accessDate: 05-04-2011], Ewing's Family of Tumours[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Tumors of the Ewing's Family[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Ewing's sarcoma[accessedResource: SNOMEDCT:76909002][accessDate: 05-04-2011], Askin's tumor[accessedResource: DOID:3369][accessDate: 05-04-2011], A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.[accessedResource: NCIt:C27291][accessDate: 05-04-2011], A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. (From Dorland, 27th ed; Stedman, 25th ed)[accessedResource: MSH:D012512][accessDate: 05-04-2011], Ewing's Family of Tumors[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Askin tumor (morphologic abnormality)[accessedResource: DOID:3369][accessDate: 05-04-2011], Sarcoma, Ewings[accessedResource: MSH:D012512][accessDate: 05-04-2011], Ewing sarcoma family of tumors[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor[accessedResource: NCIt:C27291][accessDate: 05-04-2011], Ewing's Tumor[accessedResource: NCIt:C4817][accessDate: 05-04-2011], Ewing's tumour[accessedResource: SNOMEDCT:76909002][accessDate: 05-04-2011], Tumors of Ewing's Family[accessedResource: NCIt:C27291][accessDate: 05-04-2011], A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.[accessedResource: NCIt:C4817][accessDate: 05-04-2011]

term editor

Tomasz Adamusiak, James Malone