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neoplasm of mature B-cells

^ http://www.ebi.ac.uk/efo/EFO_0000096


The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003

A low-grade malignant lymphoma of follicular pattern in which there is no clear preponderance of one cell type (small or large) over another. The large cells, cleaved or noncleaved, are often 2-3 times larger in diameter than normal lymphocytes.

Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.

Malignant lymphoma in which the majority of neoplastic cells within the follicles are large cleaved or noncleaved cells. The degree to which the follicular center cells retain their ability to form follicles varies with the state of B-cell transformation.

A low-grade malignant lymphoma of predominantly follicular pattern. Follicles are of relatively uniform size and shape and the cells are usually somewhat larger than normal lymphocytes. Nuclei are irregular with prominent indentations and cytoplasm can rarely be identified. Cells exhibiting these characteristics are often called centrocytes.

Synonyms: Lymphoma, Nodular, Mixed Lymphocytic Histiocytic, LYMPHOMA FOLLIC SMALL LARGE CLEAVED, LYMPHOMA LARGE FOLLIC, Lymphoma, Large Lymphoid, Nodular, Nodular Histiocytic Lymphomas, B-Cell Non Hodgkin's Lymphoma, Lymphoma, Small Cleaved-Cell, Follicular, FOLLIC MIXED LYMPHOMA, Lymphoma, Small Lymphoid, Follicular, Lymphoma, Mixed-Cell, Follicular, Lymphoma, Follicular, Mixed Cell, B-Cell Non-Hodgkin Lymphoma, LYMPHOMA SMALL FOLLIC CENTER, LYMPHOMA SMALL LYMPHOID FOLLIC, Lymphoma, Large-Cell, Follicular, Small Follicular Center-Cell Lymphoma, peripheral B-cell neoplasm, LYMPHOMA FOLLIC MIXED, Small Cleaved-Cell Lymphoma, Follicular, Nodular Large Follicular Center Cell Lymphoma, LYMPHOMA MIXED FOLLIC, Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic, Non-Hodgkin's B-Cell Lymphoma, Follicular Large-Cell Lymphomas, Lymphomas, Follicular Mixed-Cell, LYMPHOMA NODULAR MIXED SMALL LARGE, LYMPHOMA SMALL CLEAVED FOLLIC, Lymphocytic Lymphoma, Nodular, Poorly Differentiated, Lymphoma, Nodular Histiocytic, Lymphoma, Follicular, Follicular Lymphoma, Giant, LYMPHOMA LYMPHOCYTIC NODULAR POORLY DIFFER, Lymphoma, Giant Follicular, Lymphomas, Follicular Large-Cell, FOLLIC LARGE LYMPHOMA, Follicular Lymphomas, BRILL SYMMERS DIS, Lymphomas, Follicular, Lymphomas, Giant Follicular, Nodular Large Follicular Center-Cell Lymphoma, LYMPHOMA SMALL CLEAVED CELL FOLLIC, LYMPHOMA FOLLIC MIXED SMALL LARGE LYMPHOID, Follicular Mixed-Cell Lymphoma, Lymphomas, Nodular, B-Cell Non-Hodgkin's Lymphoma, Lymphoma, Histiocytic, Nodular, Follicular Large-Cell Lymphoma, LYMPHOMA GIANT FOLLIC, Lymphoma, Nodular, Large Follicular Center-Cell, Follicular Lymphoma, Grade 3, Follicular Lymphoma, Grade 1, Lymphoma, Follicular, Grade 3, Follicular Lymphoma, Grade 2, Lymphoma, Follicular, Grade 2, Lymphoma, Follicular Large-Cell, Lymphoma, Follicular, Grade 1, Lymphoma, Small Cleaved Cell, Follicular, LYMPHOMA FOLLIC LARGE, Follicular Lymphoma, FOLLIC LYMPHOMA GIANT, LYMPHOMA FOLLIC, Large-Cell Lymphoma, Follicular, Non-Hodgkin's Lymphoma B-Cell, Mixed-Cell Lymphoma, Follicular, Giant Follicular Lymphoma, Large-Cell Lymphomas, Follicular, Lymphoma, Small Follicular Center Cell, FOLLIC LYMPHOMA, Lymphoma, Follicular Large Cell, Lymphoma, Lymphocytic, Nodular, Poorly Differentiated, Large Lymphoid Lymphoma, Nodular, Lymphoma, Follicular Mixed-Cell, MIXED LYMPHOMA FOLLIC, Lymphoma, Follicular, Small and Large Cleaved Cell, Follicular Lymphomas, Giant, Lymphoma, Follicular, Mixed Small and Large Lymphoid, Lymphoma, Nodular, Mixed Small and Large Cell, Histiocytic Lymphomas, Nodular, Lymphoma, Follicular, Small and Large Cleaved-Cell, SMALL FOLLIC CENTER LYMPHOMA, NODULAR LARGE FOLLIC CENTER LYMPHOMA, Giant Follicular Lymphomas, LYMPHOMA NODULAR LARGE FOLLIC CENTER, Disease, Brill-Symmers, Nodular Lymphomas, Brill Symmers Disease, Nodular Histiocytic Lymphoma, Nodular Lymphoma, Histiocytic Lymphoma, Nodular, Mixed-Cell Lymphomas, Follicular, Lymphomas, Nodular Histiocytic, Lymphoma, Nodular, Large Follicular Center Cell, LYMPHOCYTIC LYMPHOMA NODULAR POORLY DIFFER, Lymphoma, Small Follicular Center-Cell, GIANT FOLLIC LYMPHOMA, Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic, Lymphocytic Lymphoma, Nodular, Poorly-Differentiated, Lymphoma, Nodular, Small Cleaved Cell Lymphoma, Follicular, Lymphomas Non-Hodgkin's B-Cell, Follicular Mixed-Cell Lymphomas, Mixed Cell Lymphoma, Follicular, Brill-Symmers Disease, Large Cell Lymphoma, Follicular, Small Follicular Center Cell Lymphoma, Lymphoma, Large Cell, Follicular, Follicular Large Cell Lymphoma, LYMPHOMA FOLLIC MIXED LYMPHOCYTIC HISTIOCYTIC, SMALL CLEAVED LYMPHOMA FOLLIC, LARGE LYMPHOMA FOLLIC, Follicular Mixed Cell Lymphoma, Lymphoma, Lymphocytic, Nodular, Poorly-Differentiated, B-cell lymphoma

Term info

DOID definition citation

DOID:707, DOID:706, DOID:0050873

NCI Thesaurus definition citation

NCIt:C3209, NCIt:C27907, NCIt:C3457

SNOMEDCT definition citation

SNOMEDCT:55020008, SNOMEDCT:40411000, SNOMEDCT:55150002, SNOMEDCT:46744002, SNOMEDCT:269476000

bioportal provenance

Histiocytic Lymphomas, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular Histiocytic[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Mixed-Cell Lymphomas[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Mixed-Cell, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Large-Cell Lymphomas[accessedResource: MSH:D008224][accessDate: 05-04-2011], GIANT FOLLIC LYMPHOMA[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Giant Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Mixed-Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA SMALL LYMPHOID FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Brill-Symmers Disease[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular, Mixed Small and Large Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Large-Cell, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Small Follicular Center Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], LARGE LYMPHOMA FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Brill Symmers Disease[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Lymphoma, Grade 3[accessedResource: MSH:D008224][accessDate: 05-04-2011], The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003[accessedResource: C3457][accessDate: 05-04-2011], LYMPHOMA FOLLIC LARGE[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphomas Non-Hodgkin's B-Cell[accessedResource: C3457][accessDate: 05-04-2011], Lymphomas, Follicular Large-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], A low-grade malignant lymphoma of predominantly follicular pattern. Follicles are of relatively uniform size and shape and the cells are usually somewhat larger than normal lymphocytes. Nuclei are irregular with prominent indentations and cytoplasm can rarely be identified. Cells exhibiting these characteristics are often called centrocytes.[accessedResource: MSH:D008224][accessDate: 05-04-2011], Mixed-Cell Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Lymphoma, Grade 2[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Lymphocytic, Nodular, Poorly-Differentiated[accessedResource: MSH:D008224][accessDate: 05-04-2011], Nodular Lymphomas[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphomas, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Small Follicular Center-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Nodular Histiocytic Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Nodular Large Follicular Center Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Mixed Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA LYMPHOCYTIC NODULAR POORLY DIFFER[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Grade 2[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA FOLLIC MIXED SMALL LARGE LYMPHOID[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA SMALL FOLLIC CENTER[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Small Cleaved Cell, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA SMALL CLEAVED FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular, Mixed Lymphocytic Histiocytic[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], BRILL SYMMERS DIS[accessedResource: MSH:D008224][accessDate: 05-04-2011], B-Cell Non-Hodgkin's Lymphoma[accessedResource: C3457][accessDate: 05-04-2011], Follicular Large-Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Mixed Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Small Cleaved Cell Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Grade 3[accessedResource: MSH:D008224][accessDate: 05-04-2011], SMALL FOLLIC CENTER LYMPHOMA[accessedResource: MSH:D008224][accessDate: 05-04-2011], Mixed-Cell Lymphomas, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Malignant lymphoma in which the majority of neoplastic cells within the follicles are large cleaved or noncleaved cells. The degree to which the follicular center cells retain their ability to form follicles varies with the state of B-cell transformation.[accessedResource: MSH:D008224][accessDate: 05-04-2011], Mixed Cell Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Small Follicular Center-Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Large Lymphoid, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Small Lymphoid, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Large Lymphoid Lymphoma, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Grade 1[accessedResource: MSH:D008224][accessDate: 05-04-2011], Nodular Histiocytic Lymphomas[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA LARGE FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], B-Cell Non-Hodgkin Lymphoma[accessedResource: C3457][accessDate: 05-04-2011], NODULAR LARGE FOLLIC CENTER LYMPHOMA[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphocytic Lymphoma, Nodular, Poorly-Differentiated[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Lymphoma, Grade 1[accessedResource: MSH:D008224][accessDate: 05-04-2011], FOLLIC LYMPHOMA[accessedResource: MSH:D008224][accessDate: 05-04-2011], Giant Follicular Lymphomas[accessedResource: MSH:D008224][accessDate: 05-04-2011], Giant Follicular Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Lymphoma, Giant[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Mixed Small and Large Lymphoid[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Lymphomas, Giant[accessedResource: MSH:D008224][accessDate: 05-04-2011], FOLLIC LARGE LYMPHOMA[accessedResource: MSH:D008224][accessDate: 05-04-2011], Non-Hodgkin's Lymphoma B-Cell[accessedResource: C3457][accessDate: 05-04-2011], Follicular Lymphomas[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA SMALL CLEAVED CELL FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphomas, Giant Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA NODULAR LARGE FOLLIC CENTER[accessedResource: MSH:D008224][accessDate: 05-04-2011], Small Follicular Center Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular, Large Follicular Center-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Small Cleaved-Cell, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular, Large Follicular Center Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Small Cleaved-Cell Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], FOLLIC LYMPHOMA GIANT[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA NODULAR MIXED SMALL LARGE[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA FOLLIC MIXED LYMPHOCYTIC HISTIOCYTIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA FOLLIC MIXED[accessedResource: MSH:D008224][accessDate: 05-04-2011], Disease, Brill-Symmers[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphomas, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular Large-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Histiocytic, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular Mixed-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], FOLLIC MIXED LYMPHOMA[accessedResource: MSH:D008224][accessDate: 05-04-2011], Large-Cell Lymphomas, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular, Small and Large Cleaved Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Follicular Large Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Nodular Large Follicular Center-Cell Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], Large-Cell Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOCYTIC LYMPHOMA NODULAR POORLY DIFFER[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA MIXED FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], MIXED LYMPHOMA FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphomas, Follicular Mixed-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Histiocytic Lymphoma, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphocytic Lymphoma, Nodular, Poorly Differentiated[accessedResource: MSH:D008224][accessDate: 05-04-2011], Non-Hodgkin's B-Cell Lymphoma[accessedResource: C3457][accessDate: 05-04-2011], B-Cell Non Hodgkin's Lymphoma[accessedResource: C3457][accessDate: 05-04-2011], Lymphoma, Follicular, Small and Large Cleaved-Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Follicular Large Cell[accessedResource: MSH:D008224][accessDate: 05-04-2011], Large Cell Lymphoma, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA GIANT FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Large Cell, Follicular[accessedResource: MSH:D008224][accessDate: 05-04-2011], A low-grade malignant lymphoma of follicular pattern in which there is no clear preponderance of one cell type (small or large) over another. The large cells, cleaved or noncleaved, are often 2-3 times larger in diameter than normal lymphocytes.[accessedResource: MSH:D008224][accessDate: 05-04-2011], SMALL CLEAVED LYMPHOMA FOLLIC[accessedResource: MSH:D008224][accessDate: 05-04-2011], Nodular Lymphoma[accessedResource: MSH:D008224][accessDate: 05-04-2011], LYMPHOMA FOLLIC SMALL LARGE CLEAVED[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphoma, Lymphocytic, Nodular, Poorly Differentiated[accessedResource: MSH:D008224][accessDate: 05-04-2011], Lymphomas, Nodular Histiocytic[accessedResource: MSH:D008224][accessDate: 05-04-2011]

gwas trait

true

term editor

James Malone, Tomasz Adamusiak