JSON

macrophage

^ http://purl.obolibrary.org/obo/CL_0000235


A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. [ http://www.ncbi.nlm.nih.gov/pubmed/16213494 http://purl.obolibrary.org/obo/go/references/0000031 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/1919437 GOC:add ]

Synonyms: histiocyte

Term info

database cross reference
  • FMA:63261
  • BTO:0000801
  • FMA:83585
  • CALOHA:TS-0587
comment

Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.